Mus musculus Gene: Arap2
Summary
InnateDB Gene IDBG-165165.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arap2
Gene Name ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000037999
Encoded Proteins
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000047365:
The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:62602445-62766198
Strand Reverse strand
Band C3.1
Transcripts
ENSMUST00000076623 ENSMUSP00000075924
ENSMUST00000160620
ENSMUST00000159022 ENSMUSP00000125391
ENSMUST00000160419
ENSMUST00000161911 ENSMUSP00000124827
ENSMUST00000159470 ENSMUSP00000124743
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0007165 signal transduction
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005622 intracellular
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Signaling by Rho GTPases pathway
Signal Transduction pathway
Rho GTPase cycle pathway
KEGG
Endocytosis pathway
INOH
PID BIOCARTA
Adp-ribosylation factor [Biocarta view]
Rho cell motility signaling pathway [Biocarta view]
Rac1 cell motility signaling pathway [Biocarta view]
T cell receptor signaling pathway [Biocarta view]
PID NCI
Arf6 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 212285
UniGene Mm.244403 Mm.394905
RefSeq NM_178407 XM_006503830
OMIM
CCDS CCDS51506
HPRD
IMGT
MGI ID MGI:2684416
MGI Symbol Arap2
EMBL
GenPept
RNA Seq Atlas 212285