Mus musculus Gene: Gfpt1
Summary
InnateDB Gene IDBG-165337.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gfpt1
Gene Name glutamine fructose-6-phosphate transaminase 1
Synonyms 2810423A18Rik; AI324119; AI449986; GFA; GFAT; GFAT1; GFAT1m; Gfpt;
Species Mus musculus
Ensembl Gene ENSMUSG00000029992
Encoded Proteins
glutamine fructose-6-phosphate transaminase 1
glutamine fructose-6-phosphate transaminase 1
glutamine fructose-6-phosphate transaminase 1
glutamine fructose-6-phosphate transaminase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198380:
This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:87042846-87092197
Strand Forward strand
Band D1
Transcripts
ENSMUST00000032057 ENSMUSP00000032057
ENSMUST00000113658 ENSMUSP00000109288
ENSMUST00000113657 ENSMUSP00000109287
ENSMUST00000113655 ENSMUSP00000109285
ENSMUST00000150410
ENSMUST00000146410
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004360 glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0016597 amino acid binding
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006042 glucosamine biosynthetic process
GO:0006047 UDP-N-acetylglucosamine metabolic process
GO:0006048 UDP-N-acetylglucosamine biosynthetic process
GO:0006541 glutamine metabolic process
GO:0008152 metabolic process
GO:0009744 response to sucrose stimulus
GO:0016051 carbohydrate biosynthetic process
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0032922 circadian regulation of gene expression
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0051289 protein homotetramerization
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Synthesis of substrates in N-glycan biosythesis pathway
Unfolded Protein Response (UPR) pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
IRE1alpha activates chaperones pathway
Synthesis of UDP-N-acetyl-glucosamine pathway
Asparagine N-linked glycosylation pathway
XBP1(S) activates chaperone genes pathway
KEGG
Alanine, aspartate and glutamate metabolism pathway
Amino sugar and nucleotide sugar metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
IRE1alpha activates chaperones pathway
Unfolded Protein Response (UPR) pathway
Post-translational protein modification pathway
XBP1(S) activates chaperone genes pathway
Synthesis of substrates in N-glycan biosythesis pathway
Asparagine N-linked glycosylation pathway
Metabolism of proteins pathway
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
Synthesis of UDP-N-acetyl-glucosamine pathway
KEGG
Alanine, aspartate and glutamate metabolism pathway
Amino sugar and nucleotide sugar metabolism pathway
INOH
Fructose Mannose metabolism pathway
Aminosugars metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.19893
RefSeq NM_013528
OMIM
CCDS CCDS39545
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas