InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gfpt1

Summary

InnateDB Gene

IDBG-165337.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gfpt1

Gene Name

glutamine fructose-6-phosphate transaminase 1

Synonyms

2810423A18Rik; AI324119; AI449986; GFA; GFAT; GFAT1; GFAT1m; Gfpt

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029992

Encoded Proteins

IDBP-165339

glutamine fructose-6-phosphate transaminase 1

IDBP-253416

glutamine fructose-6-phosphate transaminase 1

IDBP-253418

glutamine fructose-6-phosphate transaminase 1

IDBP-253420

glutamine fructose-6-phosphate transaminase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198380:
This gene encodes the first and rate-limiting enzyme of the hexosamine pathway and controls the flux of glucose into the hexosamine pathway. The product of this gene catalyzes the formation of glucosamine 6-phosphate. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:87042846-87092197

Strand

Forward strand

Band

Transcripts

ENSMUST00000032057	ENSMUSP00000032057
ENSMUST00000113658	ENSMUSP00000109288
ENSMUST00000113657	ENSMUSP00000109287
ENSMUST00000113655	ENSMUSP00000109285
ENSMUST00000150410
ENSMUST00000146410

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004360	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0016597	amino acid binding
GO:0030246	carbohydrate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006002	fructose 6-phosphate metabolic process
GO:0006042	glucosamine biosynthetic process
GO:0006047	UDP-N-acetylglucosamine metabolic process
GO:0006048	UDP-N-acetylglucosamine biosynthetic process
GO:0006541	glutamine metabolic process
GO:0008152	metabolic process
GO:0009744	response to sucrose stimulus
GO:0016051	carbohydrate biosynthetic process
GO:0032868	response to insulin
GO:0032869	cellular response to insulin stimulus
GO:0032922	circadian regulation of gene expression
GO:0045719	negative regulation of glycogen biosynthetic process
GO:0051289	protein homotetramerization