InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gfpt1

Summary

InnateDB Protein

IDBP-165339.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gfpt1

Protein Name

glutamine fructose-6-phosphate transaminase 1

Synonyms

2810423A18Rik; AI324119; AI449986; GFA; GFAT; GFAT1; GFAT1m; Gfpt;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032057

InnateDB Gene

IDBG-165337 (Gfpt1)

Protein Structure

UniProt Annotation

Function

Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes ARNTL/BMAL1 and CRY1. {ECO:0000269PubMed:23395176}.

Subcellular Localization

Disease Associations

Tissue Specificity

Isoform 1 is predominantly expressed in hindlimb muscle and is also expressed weakly in the heart. Seems to be selectively expressed in striated muscle. {ECO:0000269PubMed:11679416}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004360	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO:0016597	amino acid binding
GO:0030246	carbohydrate binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006002	fructose 6-phosphate metabolic process
GO:0006042	glucosamine biosynthetic process
GO:0006048	UDP-N-acetylglucosamine biosynthetic process
GO:0006541	glutamine metabolic process
GO:0008152	metabolic process
GO:0009744	response to sucrose stimulus
GO:0016051	carbohydrate biosynthetic process
GO:0032869	cellular response to insulin stimulus
GO:0032922	circadian regulation of gene expression
GO:0045719	negative regulation of glycogen biosynthetic process
GO:0051289	protein homotetramerization

Cellular Component

Protein Structure and Domains

PDB ID

MGI:95698

InterPro

IPR000583 Class II glutamine amidotransferase domain
IPR001347 Sugar isomerase (SIS)
IPR005855 Glucosamine-fructose-6-phosphate aminotransferase, isomerising
IPR029055 Nucleophile aminohydrolases, N-terminal

PFAM

PF00310
PF13537
PF01380
PF13580

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P47856

PhosphoSite