Mus musculus Gene: Aco2
Summary
InnateDB Gene IDBG-165439.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aco2
Gene Name aconitase 2, mitochondrial
Synonyms Aco-2; Aco3; D10Wsu183e;
Species Mus musculus
Ensembl Gene ENSMUSG00000022477
Encoded Proteins
aconitase 2, mitochondrial
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100412:
The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:81872309-81915133
Strand Forward strand
Band E1
Transcripts
ENSMUST00000023116 ENSMUSP00000023116
ENSMUST00000157003
ENSMUST00000135198
ENSMUST00000126352
ENSMUST00000155704
ENSMUST00000144324
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003994 aconitate hydratase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0051538 3 iron, 4 sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0006099 tricarboxylic acid cycle
GO:0006101 citrate metabolic process
GO:0006102 isocitrate metabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Citric acid cycle (TCA cycle) pathway
KEGG
Citrate cycle (TCA cycle) pathway
Glyoxylate and dicarboxylate metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Citric acid cycle (TCA cycle) pathway
Metabolism of proteins pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Mitochondrial protein import pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
Pyruvate metabolism and Citric Acid (TCA) cycle pathway
Citric acid cycle (TCA cycle) pathway
KEGG
Citrate cycle (TCA cycle) pathway
Glyoxylate and dicarboxylate metabolism pathway
INOH
Citrate cycle pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_080633
OMIM
CCDS CCDS27675
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas