InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aco2

Summary

InnateDB Protein

IDBP-165441.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aco2

Protein Name

aconitase 2, mitochondrial

Synonyms

Aco-2; Aco3; D10Wsu183e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023116

InnateDB Gene

IDBG-165439 (Aco2)

Protein Structure

UniProt Annotation

Function

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003994	aconitate hydratase activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0051538	3 iron, 4 sulfur cluster binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006101	citrate metabolic process
GO:0006102	isocitrate metabolic process
GO:0008152	metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:87880

InterPro

IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel
IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha
IPR006248 Aconitase, mitochondrial-like
IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel

PFAM

PF00694
PF00330

PRINTS

PR00415

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99KI0