Version 5.4
Mus musculus Gene: Tns1
Summary
InnateDB Gene IDBG-166246.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tns1
Gene Name tensin 1
Synonyms 1110018I21Rik; 1200014E20Rik; AI648117; E030018G17Rik; E030037J05Rik; Tns
Species Mus musculus
Ensembl Gene ENSMUSG00000055322
Encoded Proteins
IDBP-623774
tensin 1
IDBP-788052
tensin 1
IDBP-788053
tensin 1
IDBP-788055
tensin 1
IDBP-788056
tensin 1
IDBP-788057
tensin 1
IDBP-788058
tensin 1
IDBP-788059
tensin 1
IDBP-788062
tensin 1
IDBP-788065
tensin 1
IDBP-788067
tensin 1
IDBP-788068
tensin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079308:
The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:73910231-74124449
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000169786 ENSMUSP00000127715
ENSMUST00000187584 ENSMUSP00000140254
ENSMUST00000191104 ENSMUSP00000140317
ENSMUST00000187691 ENSMUSP00000139844
ENSMUST00000185702 ENSMUSP00000140094
ENSMUST00000185331 ENSMUSP00000140771
ENSMUST00000189228 ENSMUSP00000139721
ENSMUST00000191527
ENSMUST00000185264
ENSMUST00000185529
ENSMUST00000191367 ENSMUSP00000140991
ENSMUST00000188942
ENSMUST00000191264
ENSMUST00000186381
ENSMUST00000189571
ENSMUST00000190389 ENSMUSP00000140448
ENSMUST00000187281 ENSMUSP00000139616
ENSMUST00000188436
ENSMUST00000191204 ENSMUSP00000140878
ENSMUST00000188208 ENSMUSP00000140837
ENSMUST00000190599
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0007044 cell-substrate junction assembly
GO:0010761 fibroblast migration
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005925 focal adhesion
GO:0030055 cell-substrate junction
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000079308
View Gene Order
ENSBTAG00000002485
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
ilk_pathway
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 21961
UniGene
RefSeq NM_001289895 NM_027884 XM_006495868 XM_006495869 XM_006495870
OMIM
CCDS CCDS48288
HPRD
IMGT
MGI ID MGI:104552
MGI Symbol Tns1
EMBL
GenPept
RNA Seq Atlas 21961

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca