Homo sapiens Gene: TNS1
Summary
InnateDB Gene IDBG-80769.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNS1
Gene Name tensin 1
Synonyms MST091; MST122; MST127; MSTP122; MSTP127; MXRA6; PPP1R155; TNS;
Species Homo sapiens
Ensembl Gene ENSG00000079308
Encoded Proteins
tensin 1
tensin 1
tensin 1
tensin 1
tensin 1
tensin 1
tensin 1
tensin 1
tensin 1
tensin 1
tensin 1
tensin 1
tensin 1
tensin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:217799789-218002995
Strand Reverse strand
Band q35
Transcripts
ENST00000171887 ENSP00000171887
ENST00000310858 ENSP00000308321
ENST00000446688 ENSP00000394171
ENST00000430930 ENSP00000406016
ENST00000419504 ENSP00000408724
ENST00000446903 ENSP00000405460
ENST00000413554 ENSP00000400383
ENST00000453356 ENSP00000414704
ENST00000413280 ENSP00000395615
ENST00000439083 ENSP00000404477
ENST00000423413 ENSP00000411349
ENST00000449814 ENSP00000393925
ENST00000490566
ENST00000480416
ENST00000495556
ENST00000479185
ENST00000480665
ENST00000492338
ENST00000465306
ENST00000611415 ENSP00000484271
ENST00000615025 ENSP00000480559
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 16 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0007044 cell-substrate junction assembly
GO:0010761 fibroblast migration
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005925 focal adhesion
GO:0009986 cell surface
GO:0030055 cell-substrate junction
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
INOH
PID BIOCARTA
Integrin signaling pathway [Biocarta view]
Erk and pi-3 kinase are necessary for collagen binding in corneal epithelia [Biocarta view]
PID NCI
Integrin-linked kinase signaling
Cross-References
SwissProt
TrEMBL Q59G71 Q9H757 Q9UFN8
UniProt Splice Variant
Entrez Gene 7145
UniGene Hs.471381 Hs.619700 Hs.663032
RefSeq NM_022648
HUGO HGNC:11973
OMIM 600076
CCDS CCDS2407
HPRD 02512
IMGT
EMBL AB209238 AC009469 AC010136 AK024948 AL117537
GenPept BAB15041 BAD92475 CAB55983
RNA Seq Atlas 7145