InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tnfrsf13c

Summary

InnateDB Gene

IDBG-166389.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tnfrsf13c

Gene Name

tumor necrosis factor receptor superfamily, member 13c

Synonyms

2010006P15Rik; BAFF-R; Baffr; Bcmd; Bcmd-1; Bcmd1; Lvis22

Species

Mus musculus

Ensembl Gene

ENSMUSG00000068105

Encoded Proteins

IDBP-166391

tumor necrosis factor receptor superfamily, member 13c

IDBP-262196

tumor necrosis factor receptor superfamily, member 13c

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25673724

Tnfrsf13c (BAFFR) expression is critical for innate immune activation and antiviral immunity. Tnfrsf13c deficiency results in reduced enforced viral replication, limited type I interferon production, and reduced adaptive immunity.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159958:
B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:82221744-82224339

Strand

Reverse strand

Band

Transcripts

ENSMUST00000089161	ENSMUSP00000086564
ENSMUST00000109535	ENSMUSP00000105161

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001782	B cell homeostasis
GO:0002636	positive regulation of germinal center formation
GO:0030890	positive regulation of B cell proliferation
GO:0031295	T cell costimulation
GO:0031296	B cell costimulation
GO:0042102	positive regulation of T cell proliferation
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0050776	regulation of immune response

Cellular Component

GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Homo sapiens

Gene ID

Gene Order

ENSG00000159958

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

mmu04060

Cytokine-cytokine receptor interaction pathway

mmu05340

Primary immunodeficiency pathway

mmu04672

Intestinal immune network for IgA production pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa05340

Primary immunodeficiency pathway

hsa04672

Intestinal immune network for IgA production pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

Q3U106

UniProt Splice Variant

Entrez Gene

72049

UniGene

Mm.240047

RefSeq

NM_028075

OMIM

CCDS

CCDS27684

HPRD

IMGT

MGI ID

MGI:1919299

MGI Symbol

Tnfrsf13c

EMBL

AC104325 AK156387

GenPept

BAE33695

RNA Seq Atlas

72049