InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TNFRSF13C

Summary

InnateDB Gene

IDBG-9491.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF13C

Gene Name

tumor necrosis factor receptor superfamily, member 13C

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000159958

Encoded Proteins

IDBP-9493

tumor necrosis factor receptor superfamily, member 13C

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25673724

[Mus musculus] Tnfrsf13c (BAFFR) expression is critical for innate immune activation and antiviral immunity. Tnfrsf13c deficiency results in reduced enforced viral replication, limited type I interferon production, and reduced adaptive immunity.

Entrez Gene

Summary

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:41925041-41926818

Strand

Reverse strand

Band

q13.2

Transcripts

ENST00000291232

ENSP00000291232

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001782	B cell homeostasis
GO:0002636	positive regulation of germinal center formation
GO:0030890	positive regulation of B cell proliferation
GO:0031295	T cell costimulation
GO:0031296	B cell costimulation
GO:0042102	positive regulation of T cell proliferation
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0050776	regulation of immune response

Cellular Component

GO:0009897	external side of plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000068105

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa05340

Primary immunodeficiency pathway

hsa04672

Intestinal immune network for IgA production pathway

INOH

PID NCI

Cross-References

SwissProt

Q96RJ3

TrEMBL

Q5H8V1

UniProt Splice Variant

Entrez Gene

115650

UniGene

Hs.344088

RefSeq

NM_052945

HUGO

HGNC:17755

OMIM

606269

CCDS

CCDS14024

HPRD

IMGT

EMBL

AB222990 AF373846 BC105123 BC112030 CH471095 EF064710 Z99716

GenPept

AAI05124 AAI12031 AAK91826 ABK41893 BAE16554 EAW60473

RNA Seq Atlas

115650