InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Arpc2

Summary

InnateDB Gene

IDBG-166451.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arpc2

Gene Name

actin related protein 2/3 complex, subunit 2

Synonyms

2210023N03Rik; 34kDa; p34-Arc

Species

Mus musculus

Ensembl Gene

ENSMUSG00000006304

Encoded Proteins

IDBP-166453

actin related protein 2/3 complex, subunit 2

IDBP-253077

actin related protein 2/3 complex, subunit 2

IDBP-253079

actin related protein 2/3 complex, subunit 2

IDBP-789354

actin related protein 2/3 complex, subunit 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163466:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:74236084-74268209

Strand

Forward strand

Band

Transcripts

ENSMUST00000006467	ENSMUSP00000006467
ENSMUST00000113820	ENSMUSP00000109451
ENSMUST00000113819	ENSMUSP00000109450
ENSMUST00000185733	ENSMUSP00000140762

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0019894	kinesin binding
GO:0035650	AP-1 adaptor complex binding
GO:0071933	Arp2/3 complex binding

Biological Process

GO:0010592	positive regulation of lamellipodium assembly
GO:0030833	regulation of actin filament polymerization
GO:0030838	positive regulation of actin filament polymerization
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading

Cellular Component

GO:0005737	cytoplasm
GO:0005768	endosome
GO:0005794	Golgi apparatus
GO:0005856	cytoskeleton
GO:0005885	Arp2/3 protein complex
GO:0005886	plasma membrane
GO:0005925	focal adhesion
GO:0031252	cell leading edge
GO:0043005	neuron projection
GO:0045202	synapse
GO:0070062	extracellular vesicular exosome