Mus musculus Gene: Arpc2
Summary
InnateDB Gene IDBG-166451.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arpc2
Gene Name actin related protein 2/3 complex, subunit 2
Synonyms 2210023N03Rik; 34kDa; p34-Arc;
Species Mus musculus
Ensembl Gene ENSMUSG00000006304
Encoded Proteins
actin related protein 2/3 complex, subunit 2
actin related protein 2/3 complex, subunit 2
actin related protein 2/3 complex, subunit 2
actin related protein 2/3 complex, subunit 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163466:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:74236084-74268209
Strand Forward strand
Band C3
Transcripts
ENSMUST00000006467 ENSMUSP00000006467
ENSMUST00000113820 ENSMUSP00000109451
ENSMUST00000113819 ENSMUSP00000109450
ENSMUST00000185733 ENSMUSP00000140762
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0019894 kinesin binding
GO:0035650 AP-1 adaptor complex binding
GO:0071933 Arp2/3 complex binding
Biological Process
GO:0010592 positive regulation of lamellipodium assembly
GO:0030833 regulation of actin filament polymerization
GO:0030838 positive regulation of actin filament polymerization
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Cellular Component
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005794 Golgi apparatus
GO:0005856 cytoskeleton
GO:0005885 Arp2/3 protein complex
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0031252 cell leading edge
GO:0043005 neuron projection
GO:0045202 synapse
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Regulation of actin dynamics for phagocytic cup formation pathway
Immune System pathway
EPH-Ephrin signaling pathway
EPHB-mediated forward signaling pathway
Axon guidance pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
Developmental Biology pathway
KEGG
Fc gamma R-mediated phagocytosis pathway
Regulation of actin cytoskeleton pathway
Bacterial invasion of epithelial cells pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Regulation of actin dynamics for phagocytic cup formation pathway
Developmental Biology pathway
EPHB-mediated forward signaling pathway
Innate Immune System pathway
Axon guidance pathway
Immune System pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
EPH-Ephrin signaling pathway
KEGG
Fc gamma R-mediated phagocytosis pathway
Regulation of actin cytoskeleton pathway
Bacterial invasion of epithelial cells pathway
Pathogenic Escherichia coli infection pathway
Shigellosis pathway
INOH
PID BIOCARTA
Y branching of actin filaments [Biocarta view]
How does salmonella hijack a cell [Biocarta view]
Role of pi3k subunit p85 in regulation of actin organization and cell migration [Biocarta view]
PID NCI
ErbB1 downstream signaling
RAC1 signaling pathway
CDC42 signaling events
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 76709
UniGene
RefSeq NM_029711 XM_006496317
OMIM
CCDS CCDS35612
HPRD
IMGT
MGI ID MGI:1923959
MGI Symbol Arpc2
EMBL
GenPept
RNA Seq Atlas 76709