Version 5.4
Mus musculus Gene: Lhx2
Summary
InnateDB Gene IDBG-166617.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lhx2
Gene Name LIM homeobox protein 2
Synonyms ap; apterous; Lh-2; LH2A; Lim2
Species Mus musculus
Ensembl Gene ENSMUSG00000000247
Encoded Proteins
IDBP-166619
LIM homeobox protein 2
IDBP-539913
LIM homeobox protein 2
IDBP-541182
LIM homeobox protein 2
IDBP-539002
LIM homeobox protein 2
IDBP-718752
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106689:
This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:38339281-38369733
Strand Forward strand
Band B
Transcripts
ENSMUST00000000253 ENSMUSP00000000253
ENSMUST00000143783 ENSMUSP00000114797
ENSMUST00000149664
ENSMUST00000133661 ENSMUSP00000115179
ENSMUST00000155964 ENSMUSP00000121462
ENSMUST00000175896
ENSMUST00000176229 ENSMUSP00000135402
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001843 neural tube closure
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007498 mesoderm development
GO:0009953 dorsal/ventral pattern formation
GO:0021537 telencephalon development
GO:0021772 olfactory bulb development
GO:0021978 telencephalon regionalization
GO:0021987 cerebral cortex development
GO:0022008 neurogenesis
GO:0030182 neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048675 axon extension
GO:0060041 retina development in camera-type eye
GO:2000678 negative regulation of transcription regulatory region DNA binding
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000106689
View Gene Order
Cross-References
SwissProt
TrEMBL F6SM03 F6Z9H5
UniProt Splice Variant
Entrez Gene 16870
UniGene Mm.142856
RefSeq NM_001290646 XM_006497737 XM_006497738 XM_006497739 NM_010710
OMIM
CCDS CCDS71048 CCDS16008
HPRD
IMGT
MGI ID MGI:96785
MGI Symbol Lhx2
EMBL AL929186 BX813320
GenPept
RNA Seq Atlas 16870

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca