Version 5.4
Homo sapiens Gene: LHX2
Summary
InnateDB Gene IDBG-84682.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LHX2
Gene Name LIM homeobox 2
Synonyms hLhx2; LH2
Species Homo sapiens
Ensembl Gene ENSG00000106689
Encoded Proteins
IDBP-84684
LIM homeobox 2
IDBP-379931
LIM homeobox 2
IDBP-808748
LIM homeobox 2
IDBP-597898
LIM homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:124001670-124033301
Strand Forward strand
Band q33.3
Transcripts
ENST00000373615 ENSP00000362717
ENST00000446480 ENSP00000394978
ENST00000488674 ENSP00000476200
ENST00000560961 ENSP00000453448
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001843 neural tube closure
GO:0006366 transcription from RNA polymerase II promoter
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007420 brain development
GO:0007498 mesoderm development
GO:0009953 dorsal/ventral pattern formation
GO:0021537 telencephalon development
GO:0021772 olfactory bulb development
GO:0021978 telencephalon regionalization
GO:0021987 cerebral cortex development
GO:0022008 neurogenesis
GO:0030182 neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048675 axon extension
GO:0060041 retina development in camera-type eye
GO:2000678 negative regulation of transcription regulatory region DNA binding
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000000247
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 9355
UniGene
RefSeq NM_004789 XM_006717323
HUGO HGNC:6594
OMIM 603759
CCDS CCDS6853
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 9355

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca