Mus musculus Gene: Ror1
Summary
InnateDB Gene IDBG-166833.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ror1
Gene Name receptor tyrosine kinase-like orphan receptor 1
Synonyms 2810404D04Rik; mRor1; Ntrkr1;
Species Mus musculus
Ensembl Gene ENSMUSG00000035305
Encoded Proteins
receptor tyrosine kinase-like orphan receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185483:
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:100095791-100444765
Strand Forward strand
Band C6
Transcripts
ENSMUST00000039630 ENSMUSP00000048171
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017147 Wnt-protein binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0018108 peptidyl-tyrosine phosphorylation
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0043235 receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
Wnt pathway
REACTOME
PCP/CE pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Signal Transduction pathway
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.391716 Mm.485829 Mm.57252
RefSeq NM_013845 XM_006503120
OMIM
CCDS CCDS18389
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas