InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ror1

Summary

InnateDB Protein

IDBP-166835.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ror1

Protein Name

receptor tyrosine kinase-like orphan receptor 1

Synonyms

2810404D04Rik; mRor1; Ntrkr1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048171

InnateDB Gene

IDBG-166833 (Ror1)

Protein Structure

UniProt Annotation

Function

Tyrosine-protein kinase receptor whose role is not yet clear.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017147	Wnt-protein binding

Biological Process

GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0018108	peptidyl-tyrosine phosphorylation

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:1347520

InterPro

IPR000001 Kringle
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin
IPR013806 Kringle-like fold
IPR016247 Tyrosine-protein kinase, receptor ROR
IPR020067 Frizzled domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM