InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Flt4

Summary

InnateDB Gene

IDBG-167138.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Flt4

Gene Name

FMS-like tyrosine kinase 4

Synonyms

AI323512; Chy; Flt-4; VEGFR-3; VEGFR3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020357

Encoded Proteins

IDBP-167140

FMS-like tyrosine kinase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24656836

Flt4 signalling represents a negative feedback mechanism by immune cells to overreacting during bacterial infection; ligation of Flt4 by Vegfc reduces TLR4-triggered production of proinflammatory cytokines in macrophages.

InnateDB Annotation from Orthologs

Summary

PMID 24656836

[Homo sapiens] FLT4 signalling represents a negative feedback mechanism by immune cells to overreacting during bacterial infection; where ligation of FLT4 by VEGFC reduces TLR4-triggered production of proinflammatory cytokines in macrophages.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000037280:
This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:49609263-49652739

Strand

Forward strand

Band

B1.2

Transcripts

ENSMUST00000020617	ENSMUSP00000020617
ENSMUST00000152253

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005021	vascular endothelial growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0019903	protein phosphatase binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001944	vasculature development
GO:0001945	lymph vessel development
GO:0001946	lymphangiogenesis
GO:0002040	sprouting angiogenesis
GO:0006468	protein phosphorylation
GO:0008284	positive regulation of cell proliferation
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010595	positive regulation of endothelial cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0043410	positive regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0046330	positive regulation of JNK cascade
GO:0046777	protein autophosphorylation
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048514	blood vessel morphogenesis
GO:0060312	regulation of blood vessel remodeling
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090037	positive regulation of protein kinase C signaling