InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: FLT4

Summary

InnateDB Gene

IDBG-62355.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FLT4

Gene Name

fms-related tyrosine kinase 4

Synonyms

FLT41; LMPH1A; PCL; VEGFR3

Species

Homo sapiens

Ensembl Gene

ENSG00000037280

Encoded Proteins

IDBP-62357

fms-related tyrosine kinase 4

IDBP-243794

fms-related tyrosine kinase 4

IDBP-483704

fms-related tyrosine kinase 4

IDBP-480250

fms-related tyrosine kinase 4

IDBP-810424

fms-related tyrosine kinase 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24656836

FLT4 signalling represents a negative feedback mechanism by immune cells to overreacting during bacterial infection; where ligation of FLT4 by VEGFC reduces TLR4-triggered production of proinflammatory cytokines in macrophages.

InnateDB Annotation from Orthologs

Summary

PMID 24656836

[Mus musculus] Flt4 signalling represents a negative feedback mechanism by immune cells to overreacting during bacterial infection; ligation of Flt4 by Vegfc reduces TLR4-triggered production of proinflammatory cytokines in macrophages.

Entrez Gene

Summary

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:180601506-180649624

Strand

Reverse strand

Band

q35.3

Transcripts

ENST00000261937	ENSP00000261937
ENST00000393347	ENSP00000377016
ENST00000424276
ENST00000502603
ENST00000507059
ENST00000502649	ENSP00000426057
ENST00000510000
ENST00000514810
ENST00000512795	ENSP00000421535
ENST00000502293
ENST00000513527
ENST00000619105	ENSP00000481134

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0005021	vascular endothelial growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019838	growth factor binding
GO:0019903	protein phosphatase binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0001938	positive regulation of endothelial cell proliferation
GO:0001944	vasculature development
GO:0001945	lymph vessel development
GO:0001946	lymphangiogenesis
GO:0002040	sprouting angiogenesis
GO:0006468	protein phosphorylation
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0010595	positive regulation of endothelial cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0043410	positive regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0046330	positive regulation of JNK cascade
GO:0046777	protein autophosphorylation
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048514	blood vessel morphogenesis
GO:0060312	regulation of blood vessel remodeling
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0090037	positive regulation of protein kinase C signaling

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0043235	receptor complex