InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cnot6

Summary

InnateDB Gene

IDBG-167338.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cnot6

Gene Name

CCR4-NOT transcription complex, subunit 6

Synonyms

CCR4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020362

Encoded Proteins

IDBP-167340

CCR4-NOT transcription complex, subunit 6

IDBP-531682

CCR4-NOT transcription complex, subunit 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113300:
The protein encoded by this gene is a subunit of the CCR4-NOT core transcriptional regulation complex. The encoded protein has a 3'-5' RNase activity and prefers polyadenylated substates. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:49671503-49712723

Strand

Reverse strand

Band

B1.2

Transcripts

ENSMUST00000020624	ENSMUSP00000020624
ENSMUST00000109183
ENSMUST00000145353	ENSMUSP00000121239
ENSMUST00000145424
ENSMUST00000151090

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004532	exoribonuclease activity
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006417	regulation of translation
GO:0008284	positive regulation of cell proliferation
GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly
GO:0031047	gene silencing by RNA
GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic
GO:2000327	positive regulation of ligand-dependent nuclear receptor transcription coactivator activity

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0030014	CCR4-NOT complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000113300

View Gene Order

ENSBTAG00000017362

Not yet available

Pathways

NETPATH

REACTOME

REACT_244119

Deadenylation of mRNA pathway

REACT_233572

Gene Expression pathway

REACT_235784

Deadenylation-dependent mRNA decay pathway

KEGG

mmu03018

RNA degradation pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_20514

Deadenylation of mRNA pathway

REACT_20639

Deadenylation-dependent mRNA decay pathway

REACT_71

Gene Expression pathway

KEGG

hsa03018

RNA degradation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.247113 Mm.431753 Mm.475441 Mm.487524

RefSeq

NM_001290741 NM_212484 XM_006531940 XM_006531941 XM_006531942 XM_006531943 XM_006531944

OMIM

CCDS

CCDS24621 CCDS70172

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas