Homo sapiens Gene: C3AR1
Summary
InnateDB Gene IDBG-16768.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C3AR1
Gene Name complement component 3a receptor 1
Synonyms AZ3B; C3AR; HNFAG09;
Species Homo sapiens
Ensembl Gene ENSG00000171860
Encoded Proteins
complement component 3a receptor 1
complement component 3a receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Mus musculus] C3a and its receptor C3ar1 are critical for defense against C. psittaci in mouse lung infection.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 12:8058302-8066471
Strand Reverse strand
Band p13.31
Transcripts
ENST00000307637 ENSP00000302079
ENST00000546241 ENSP00000444500
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004876 complement component C3a receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004943 C3a anaphylatoxin receptor activity
Biological Process
GO:0002430 complement receptor mediated signaling pathway
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0008015 blood circulation
GO:0008152 metabolic process
GO:0010575 positive regulation vascular endothelial growth factor production
GO:0010759 positive regulation of macrophage chemotaxis
GO:0045766 positive regulation of angiogenesis
GO:0090023 positive regulation of neutrophil chemotaxis
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Class A/1 (Rhodopsin-like receptors) pathway
Signaling by GPCR pathway
Peptide ligand-binding receptors pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
GPCR ligand binding pathway
KEGG
Neuroactive ligand-receptor interaction pathway
Complement and coagulation cascades pathway
Staphylococcus aureus infection pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F5GZE6
UniProt Splice Variant
Entrez Gene 719
UniGene Hs.591148
RefSeq NM_004054
HUGO HGNC:1319
OMIM 605246
CCDS CCDS8588
HPRD 05581
IMGT
EMBL AC006511
GenPept
RNA Seq Atlas 719