Mus musculus Gene: S100a1
Summary
InnateDB Gene IDBG-167722.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol S100a1
Gene Name S100 calcium binding protein A1
Synonyms AI266795; S100; S100a;
Species Mus musculus
Ensembl Gene ENSMUSG00000044080
Encoded Proteins
S100 calcium binding protein A1
S100 calcium binding protein A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160678:
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:90511034-90514392
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000060738 ENSMUSP00000058237
ENSMUST00000107340 ENSMUSP00000102963
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044548 S100 protein binding
GO:0048306 calcium-dependent protein binding
GO:0051117 ATPase binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0008016 regulation of heart contraction
GO:0021762 substantia nigra development
GO:1901387 positive regulation of voltage-gated calcium channel activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016529 sarcoplasmic reticulum
GO:0030018 Z disc
GO:0031430 M band
GO:0031672 A band
GO:0031674 I band
GO:0043005 neuron projection
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL Q91V77
UniProt Splice Variant
Entrez Gene 20193
UniGene
RefSeq NM_011309
OMIM
CCDS CCDS38503
HPRD
IMGT
MGI ID MGI:1338917
MGI Symbol S100a1
EMBL AC160552 AF368423 AK002721 AK012578 AK168822 BC005590 CH466547
GenPept AAH05590 AAL14436 BAB22308 BAB28330 BAE40649 EDL15127
RNA Seq Atlas 20193