Homo sapiens Gene: S100A1
Summary
InnateDB Gene IDBG-102741.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol S100A1
Gene Name S100 calcium binding protein A1
Synonyms S100; S100-alpha; S100A;
Species Homo sapiens
Ensembl Gene ENSG00000160678
Encoded Proteins
S100 calcium binding protein A1
S100 calcium binding protein A1
S100 calcium binding protein A1
S100 calcium binding protein A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:153627926-153632039
Strand Forward strand
Band q21.3
Transcripts
ENST00000368698 ENSP00000357687
ENST00000292169 ENSP00000292169
ENST00000368696 ENSP00000357685
ENST00000436839 ENSP00000389708
ENST00000469893
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0044548 S100 protein binding
GO:0048306 calcium-dependent protein binding
GO:0051117 ATPase binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0008016 regulation of heart contraction
GO:0021762 substantia nigra development
GO:0035556 intracellular signal transduction
GO:1901387 positive regulation of voltage-gated calcium channel activity
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016529 sarcoplasmic reticulum
GO:0030018 Z disc
GO:0031430 M band
GO:0031672 A band
GO:0031674 I band
GO:0043005 neuron projection
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL Q5T7Y4 Q5T7Y5
UniProt Splice Variant
Entrez Gene 6271
UniGene
RefSeq NM_006271
HUGO HGNC:10486
OMIM 176940
CCDS CCDS1047
HPRD 01489
IMGT
EMBL AL162258
GenPept
RNA Seq Atlas 6271