Version 5.4
Mus musculus Gene: Cast
Summary
InnateDB Gene IDBG-167762.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cast
Gene Name calpastatin
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000021585
Encoded Proteins
IDBP-167764
calpastatin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an inhibitor of the calcium-dependent cysteine protease, calpain. This protein plays roles in multiple processes, including apoptosis, cell cycle regulation, and membrane fusion. Multiple protein isoforms exist which contain unique N-terminal domains, and multiple inhibitory domains that share homology with each other. Some isoforms may be tissue-specific. Two different pseudogenes of this gene are found on chromosome 19. [provided by RefSeq, Jul 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:74694286-74807921
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000065629 ENSMUSP00000065275
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0010466 negative regulation of peptidase activity
GO:0030163 protein catabolic process
GO:2000675 negative regulation of type B pancreatic cell apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000153113
View Gene Order
ENSBTAG00000000874
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL Q8C281 Q8CE80 Q921U7
UniProt Splice Variant
Entrez Gene 12380
UniGene Mm.29163
RefSeq NM_009817 XM_006517055 XM_006517059 XM_006517066 XM_006517071
OMIM
CCDS CCDS26648
HPRD
IMGT
MGI ID MGI:1098236
MGI Symbol Cast
EMBL AC138120 AC154780 AK028843 AK089108 BC010603
GenPept AAH10603 BAC26149 BAC40755
RNA Seq Atlas 12380

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca