Version 5.4
Homo sapiens Gene: CAST
Summary
InnateDB Gene IDBG-34327.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CAST
Gene Name calpastatin
Synonyms BS-17
Species Homo sapiens
Ensembl Gene ENSG00000153113
Encoded Proteins
IDBP-34329
calpastatin
IDBP-34333
calpastatin
IDBP-34337
calpastatin
IDBP-34341
calpastatin
IDBP-238675
calpastatin
IDBP-238677
calpastatin
IDBP-374004
calpastatin
IDBP-374018
calpastatin
IDBP-477630
calpastatin
IDBP-479953
calpastatin
IDBP-479444
calpastatin
IDBP-474662
calpastatin
IDBP-477567
calpastatin
IDBP-475078
calpastatin
IDBP-485222
calpastatin
IDBP-479863
calpastatin
IDBP-477523
calpastatin
IDBP-482638
calpastatin
IDBP-477388
calpastatin
IDBP-478937
calpastatin
IDBP-473711
calpastatin
IDBP-474902
calpastatin
IDBP-478587
calpastatin
IDBP-479499
calpastatin
IDBP-478332
calpastatin
IDBP-480973
calpastatin
IDBP-476807
calpastatin
IDBP-479705
calpastatin
IDBP-480737
calpastatin
IDBP-589972
calpastatin
IDBP-478156
calpastatin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:96525267-96779595
Strand Forward strand
Band q15
Transcripts
ENST00000338252 ENSP00000343421
ENST00000325674 ENSP00000320319
ENST00000341926 ENSP00000339914
ENST00000309190 ENSP00000312523
ENST00000348386
ENST00000395813 ENSP00000379158
ENST00000395812 ENSP00000379157
ENST00000421689 ENSP00000396558
ENST00000437034 ENSP00000412374
ENST00000505143 ENSP00000422957
ENST00000508830 ENSP00000425721
ENST00000511097 ENSP00000422951
ENST00000515160
ENST00000507487
ENST00000510756 ENSP00000422176
ENST00000507836
ENST00000512620 ENSP00000426422
ENST00000514845 ENSP00000422612
ENST00000510245
ENST00000506811 ENSP00000427092
ENST00000514055 ENSP00000421230
ENST00000508608 ENSP00000422677
ENST00000505402
ENST00000511049 ENSP00000421130
ENST00000510156 ENSP00000422325
ENST00000508117 ENSP00000422466
ENST00000509903 ENSP00000426946
ENST00000511782 ENSP00000423638
ENST00000504465 ENSP00000425670
ENST00000504221
ENST00000513666
ENST00000508197 ENSP00000422831
ENST00000504532
ENST00000515063
ENST00000510500 ENSP00000424160
ENST00000508579 ENSP00000425787
ENST00000509259 ENSP00000423846
ENST00000503828 ENSP00000422807
ENST00000515663 ENSP00000422929
ENST00000484552 ENSP00000432878
ENST00000512191
ENST00000510098 ENSP00000427195
ENST00000509529
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004866 endopeptidase inhibitor activity
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
GO:2000675 negative regulation of type B pancreatic cell apoptotic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021585
View Gene Order
ENSBTAG00000000874
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.436186 Hs.655371 Hs.737461 Hs.738388
RefSeq NM_001042440 NM_001190442 NM_001284212 NM_001284213 NM_173060 XM_006714696 XM_006714697 XM_006714699 XM_006714700 XM_006714701 XM_006714702 XM_006714704 XM_006714705 XM_006714706 XM_006714707 XM_006714708 XM_006714709 XM_006714711 XM_006714713 XM_006714714 XM_006714715
HUGO
OMIM
CCDS CCDS4082 CCDS54882 CCDS54883 CCDS75279
HPRD 00233
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca