Homo sapiens Gene: GNA11
Summary
InnateDB Gene IDBG-16830.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNA11
Gene Name guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Synonyms FBH; FBH2; FHH2; GNA-11; HHC2; HYPOC2;
Species Homo sapiens
Ensembl Gene ENSG00000088256
Encoded Proteins
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:3094410-3124004
Strand Forward strand
Band p13.3
Transcripts
ENST00000078429 ENSP00000078429
ENST00000588401 ENSP00000479797
ENST00000591301
ENST00000586180
ENST00000586763
ENST00000587636 ENSP00000465935
ENST00000590534
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0031826 type 2A serotonin receptor binding
GO:0046872 metal ion binding
Biological Process
GO:0001501 skeletal system development
GO:0001508 action potential
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007507 heart development
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0045634 regulation of melanocyte differentiation
GO:0048066 developmental pigmentation
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
GO:0071467 cellular response to pH
Cellular Component
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
TSH pathway
REACTOME
Integration of energy metabolism pathway
Thrombin signalling through proteinase activated receptors (PARs) pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Acetylcholine regulates insulin secretion pathway
Free fatty acids regulate insulin secretion pathway
Thromboxane signalling through TP receptor pathway
ADP signalling through P2Y purinoceptor 1 pathway
Regulation of insulin secretion pathway
Metabolism pathway
Signal amplification pathway
Hemostasis pathway
KEGG
Calcium signaling pathway pathway
Vascular smooth muscle contraction pathway
Gap junction pathway
Long-term depression pathway
GnRH signaling pathway pathway
Chagas disease (American trypanosomiasis) pathway
Amoebiasis pathway
INOH
PID BIOCARTA
Role of egf receptor transactivation by gpcrs in cardiac hypertrophy [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.596566 Hs.614759 Hs.650575 Hs.654784 Hs.732269
RefSeq NM_002067
HUGO
OMIM
CCDS CCDS12103
HPRD 00759
IMGT
EMBL
GenPept
RNA Seq Atlas