Version 5.4
Mus musculus Gene: Mgat4b
Summary
InnateDB Gene IDBG-168402.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mgat4b
Gene Name mannoside acetylglucosaminyltransferase 4, isoenzyme B
Synonyms AA407995; GnTIVb
Species Mus musculus
Ensembl Gene ENSMUSG00000036620
Encoded Proteins
IDBP-168406
mannoside acetylglucosaminyltransferase 4, isoenzyme B
IDBP-538798
mannoside acetylglucosaminyltransferase 4, isoenzyme B
IDBP-542363
mannoside acetylglucosaminyltransferase 4, isoenzyme B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000161013:
This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1,4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:50210890-50235103
Strand Forward strand
Band B1.3
Transcripts
ENSMUST00000041725 ENSMUSP00000043346
ENSMUST00000147468 ENSMUSP00000119786
ENSMUST00000151803 ENSMUSP00000116802
ENSMUST00000133714
ENSMUST00000122977
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
GO:0016758 transferase activity, transferring hexosyl groups
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006486 protein glycosylation
GO:0008150 biological_process
Cellular Component
GO:0000139 Golgi membrane
GO:0005575 cellular_component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000161013
View Gene Order
ENSBTAG00000009738
Not yet available
Pathways
NETPATH
REACTOME
REACT_198565
N-Glycan antennae elongation pathway
REACT_198566
N-glycan antennae elongation in the medial/trans-Golgi pathway
REACT_206143
Transport to the Golgi and subsequent modification pathway
REACT_247926
Metabolism of proteins pathway
REACT_236283
Post-translational protein modification pathway
REACT_237472
Asparagine N-linked glycosylation pathway
KEGG
mmu00510
N-Glycan biosynthesis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25085
N-Glycan antennae elongation pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_25208
N-glycan antennae elongation in the medial/trans-Golgi pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q812F8
TrEMBL A8Y5H5
UniProt Splice Variant
Entrez Gene 103534
UniGene Mm.86759
RefSeq NM_145926
OMIM
CCDS CCDS24630
HPRD
IMGT
MGI ID MGI:2143974
MGI Symbol Mgat4b
EMBL AB053218 AB053219 AK155336 AL627187 BC026638 BC031613
GenPept AAH26638 AAH31613 BAC55019 BAC55020 BAE33202 CAI25119
RNA Seq Atlas 103534

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca