InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mgat4b

Summary

InnateDB Protein

IDBP-168406.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mgat4b

Protein Name

mannoside acetylglucosaminyltransferase 4, isoenzyme B

Synonyms

AA407995; GnTIVb;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043346

InnateDB Gene

IDBG-168402 (Mgat4b)

Protein Structure

UniProt Annotation

Function

Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N- linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains. Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N- glycan biosynthesis (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0046872	metal ion binding