Mus musculus Gene: Orc4
Summary
InnateDB Gene IDBG-168508.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Orc4
Gene Name origin recognition complex, subunit 4
Synonyms mMmORC4; Orc4l; Orc4P;
Species Mus musculus
Ensembl Gene ENSMUSG00000026761
Encoded Proteins
origin recognition complex, subunit 4
origin recognition complex, subunit 4
origin recognition complex, subunit 4
origin recognition complex, subunit 4
origin recognition complex, subunit 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115947:
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:48902824-48950277
Strand Reverse strand
Band C1.1
Transcripts
ENSMUST00000028098 ENSMUSP00000028098
ENSMUST00000090976 ENSMUSP00000088497
ENSMUST00000156956
ENSMUST00000154784
ENSMUST00000150492
ENSMUST00000128618
ENSMUST00000141441
ENSMUST00000142851 ENSMUSP00000119274
ENSMUST00000123789
ENSMUST00000153150
ENSMUST00000123809
ENSMUST00000149679 ENSMUSP00000121114
ENSMUST00000123271 ENSMUSP00000117732
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006810 transport
Cellular Component
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005664 nuclear origin of replication recognition complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Assembly of the ORC complex at the origin of replication pathway
Cell Cycle, Mitotic pathway
Synthesis of DNA pathway
CDT1 association with the CDC6:ORC:origin complex pathway
DNA Replication pathway
Switching of origins to a post-replicative state pathway
Cell Cycle pathway
Cell Cycle Checkpoints pathway
CDC6 association with the ORC:origin complex pathway
Regulation of DNA replication pathway
Activation of the pre-replicative complex pathway
Orc1 removal from chromatin pathway
M/G1 Transition pathway
G2/M Checkpoints pathway
E2F-enabled inhibition of pre-replication complex formation pathway
Association of licensing factors with the pre-replicative complex pathway
G1/S Transition pathway
Removal of licensing factors from origins pathway
Mitotic G1-G1/S phases pathway
Activation of ATR in response to replication stress pathway
E2F mediated regulation of DNA replication pathway
DNA Replication Pre-Initiation pathway
Assembly of the pre-replicative complex pathway
S Phase pathway
KEGG
Cell cycle pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
E2F-enabled inhibition of pre-replication complex formation pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Activation of the pre-replicative complex pathway
Cell Cycle pathway
Association of licensing factors with the pre-replicative complex pathway
Removal of licensing factors from origins pathway
E2F mediated regulation of DNA replication pathway
Switching of origins to a post-replicative state pathway
M/G1 Transition pathway
Orc1 removal from chromatin pathway
Activation of ATR in response to replication stress pathway
Cell Cycle, Mitotic pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Assembly of the ORC complex at the origin of replication pathway
CDC6 association with the ORC:origin complex pathway
Regulation of DNA replication pathway
Assembly of the pre-replicative complex pathway
Cell Cycle Checkpoints pathway
E2F-enabled inhibition of pre-replication complex formation pathway
S Phase pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Mitotic G1-G1/S phases pathway
DNA Replication Pre-Initiation pathway
DNA Replication pathway
Assembly of the pre-replicative complex pathway
Association of licensing factors with the pre-replicative complex pathway
G1/S Transition pathway
Regulation of DNA replication pathway
Orc1 removal from chromatin pathway
Cell Cycle, Mitotic pathway
E2F mediated regulation of DNA replication pathway
Synthesis of DNA pathway
Cell Cycle pathway
Assembly of the ORC complex at the origin of replication pathway
CDC6 association with the ORC:origin complex pathway
M/G1 Transition pathway
G2/M Checkpoints pathway
Activation of the pre-replicative complex pathway
Activation of ATR in response to replication stress pathway
Removal of licensing factors from origins pathway
Cell Cycle Checkpoints pathway
Switching of origins to a post-replicative state pathway
KEGG
Cell cycle pathway
INOH
PID BIOCARTA
Cdk regulation of dna replication [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL A2AI40 A2AI42 A2AI43
UniProt Splice Variant
Entrez Gene 26428
UniGene Mm.406586 Mm.421890 Mm.439060
RefSeq NM_001177313 NM_011958 XM_006498063 XM_006498064 XM_006498065
OMIM
CCDS CCDS16022 CCDS50582
HPRD
IMGT
MGI ID MGI:1347043
MGI Symbol Orc4
EMBL AL732317 AL845521 BX284644
GenPept
RNA Seq Atlas 26428