Homo sapiens Gene: ORC4
Summary
InnateDB Gene IDBG-71780.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ORC4
Gene Name origin recognition complex, subunit 4
Synonyms ORC4L; ORC4P;
Species Homo sapiens
Ensembl Gene ENSG00000115947
Encoded Proteins
origin recognition complex, subunit 4
origin recognition complex, subunit 4
origin recognition complex, subunit 4
origin recognition complex, subunit 4
origin recognition complex, subunit 4
origin recognition complex, subunit 4
origin recognition complex, subunit 4
origin recognition complex, subunit 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:147930397-148021604
Strand Reverse strand
Band q23.1
Transcripts
ENST00000264169 ENSP00000264169
ENST00000392857 ENSP00000376597
ENST00000416719 ENSP00000413939
ENST00000457954 ENSP00000391484
ENST00000440042 ENSP00000403105
ENST00000488761
ENST00000481488
ENST00000483608
ENST00000478904
ENST00000461711
ENST00000496670
ENST00000490200
ENST00000495601
ENST00000535373 ENSP00000441953
ENST00000540442 ENSP00000438326
ENST00000536575 ENSP00000441502
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
Experimentally validated
Total 39 [view]
Protein-Protein 37 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003677 DNA binding
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0017111 nucleoside-triphosphatase activity
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0006270 DNA replication initiation
GO:0006810 transport
Cellular Component
GO:0000808 origin recognition complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005664 nuclear origin of replication recognition complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
E2F-enabled inhibition of pre-replication complex formation pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Activation of the pre-replicative complex pathway
Cell Cycle pathway
Association of licensing factors with the pre-replicative complex pathway
Removal of licensing factors from origins pathway
E2F mediated regulation of DNA replication pathway
Switching of origins to a post-replicative state pathway
M/G1 Transition pathway
Orc1 removal from chromatin pathway
Activation of ATR in response to replication stress pathway
Cell Cycle, Mitotic pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Assembly of the ORC complex at the origin of replication pathway
CDC6 association with the ORC:origin complex pathway
Regulation of DNA replication pathway
Assembly of the pre-replicative complex pathway
Cell Cycle Checkpoints pathway
KEGG
Cell cycle pathway
INOH
PID BIOCARTA
Cdk regulation of dna replication [Biocarta view]
PID NCI
Cross-References
SwissProt O43929
TrEMBL B7Z632 C9J2X8 C9JGH7 Q53SE3 Q53TH5 Q96B14
UniProt Splice Variant
Entrez Gene 5000
UniGene Hs.558364
RefSeq NM_181742 NM_001190879 NM_001190881 NM_001190882 NM_002552 NM_181741 XM_006712556
HUGO HGNC:8490
OMIM 603056
CCDS CCDS2187 CCDS54404 CCDS54405
HPRD 09118
IMGT
EMBL AC009480 AC019226 AF022108 AF047598 AF132596 AK295721 AK298862 AK299749 AY600302 BC014847 BC016177 CH471058
GenPept AAC01957 AAC80282 AAD22110 AAH14847 AAH16177 AAS94326 AAX93051 AAY24232 BAH12166 BAH12887 BAH13118 EAX11555 EAX11556 EAX11557 EAX11558 EAX11560
RNA Seq Atlas 5000