InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hnrnph1

Summary

InnateDB Gene

IDBG-168689.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hnrnph1

Gene Name

heterogeneous nuclear ribonucleoprotein H1

Synonyms

AI642080; E430005G16Rik; Hnrnph; Hnrph1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000007850

Encoded Proteins

IDBP-168691

heterogeneous nuclear ribonucleoprotein H1

IDBP-168693

heterogeneous nuclear ribonucleoprotein H1

IDBP-263012

heterogeneous nuclear ribonucleoprotein H1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169045:
This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:50376990-50386528

Strand

Forward strand

Band

B1.3

Transcripts

ENSMUST00000077817	ENSMUSP00000076989
ENSMUST00000069304	ENSMUSP00000070503
ENSMUST00000109142	ENSMUSP00000104770
ENSMUST00000126737
ENSMUST00000127964
ENSMUST00000123371
ENSMUST00000150153
ENSMUST00000129631
ENSMUST00000133435
ENSMUST00000128220
ENSMUST00000134230
ENSMUST00000141668
ENSMUST00000132715
ENSMUST00000156642
ENSMUST00000150657
ENSMUST00000143301
ENSMUST00000140056
ENSMUST00000151537

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 104 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	14 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	104 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0043484	regulation of RNA splicing

Cellular Component

GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0071013	catalytic step 2 spliceosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000169045

View Gene Order

ENSBTAG00000009389

Not yet available

Pathways

NETPATH

REACTOME

REACT_249110

mRNA Splicing pathway

REACT_233572

Gene Expression pathway

REACT_260226

mRNA Splicing - Major Pathway pathway

REACT_233950

Processing of Capped Intron-Containing Pre-mRNA pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

O35737

TrEMBL

Q811L7

UniProt Splice Variant

Entrez Gene

59013

UniGene

Mm.21740 Mm.436416

RefSeq

NM_021510 XM_006533875 XM_006533876 XM_006533877 XM_006533878 XM_006533882

OMIM

CCDS

CCDS24634

HPRD

IMGT

MGI ID

MGI:1891925

MGI Symbol

Hnrnph1

EMBL

AK161491 BC042187 BC056224 CH466575 Y14196

GenPept

AAH42187 AAH56224 BAE36421 CAA74583 EDL33701

RNA Seq Atlas

59013