Version 5.4
Mus musculus Protein: Hnrnph1
Summary
InnateDB Protein IDBP-263012.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hnrnph1
Protein Name heterogeneous nuclear ribonucleoprotein H1
Synonyms AI642080; E430005G16Rik; Hnrnph; Hnrph1;
Species Mus musculus
Ensembl Protein ENSMUSP00000104770
InnateDB Gene IDBG-168689 (Hnrnph1)
Protein Structure
UniProt Annotation
Function This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG) (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 104 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 14 [view]
Protein-DNA 7 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 104 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
GO:0043484 regulation of RNA splicing
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0015629 actin cytoskeleton
GO:0071013 catalytic step 2 spliceosome
Protein Structure and Domains
PDB ID MGI:1891925
InterPro IPR000504 RNA recognition motif domain
IPR012996 Zinc finger, CHHC-type
PFAM PF00076
PF08080
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35737
PhosphoSite PhosphoSite-O35737
TrEMBL Q811L7
UniProt Splice Variant
Entrez Gene 59013
UniGene Mm.436416
RefSeq XP_006533944
MGI ID
MGI Symbol Hnrnph1
OMIM
CCDS CCDS24634
HPRD
IMGT
EMBL AK161491 BC042187 BC056224 CH466575 Y14196
GenPept AAH42187 AAH56224 BAE36421 CAA74583 EDL33701

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca