Version 5.4
Mus musculus Gene: Pnpla3
Summary
InnateDB Gene IDBG-169088.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pnpla3
Gene Name patatin-like phospholipase domain containing 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000041653
Encoded Proteins
IDBP-169090
patatin-like phospholipase domain containing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000100344:
The protein encoded by this gene is a triacylglycerol lipase that mediates triacylglycerol hydrolysis in adipocytes. The encoded protein, which appears to be membrane bound, may be involved in the balance of energy usage/storage in adipocytes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:84167816-84189512
Strand Forward strand
Band E2
Transcripts
ENSMUST00000045289 ENSMUSP00000043826
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0004806 triglyceride lipase activity
GO:0051264 mono-olein transacylation activity
GO:0051265 diolein transacylation activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0019432 triglyceride biosynthetic process
GO:0019433 triglyceride catabolic process
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000100344
View Gene Order
Pathways
NETPATH
REACTOME
REACT_199036
Acyl chain remodeling of DAG and TAG pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_188641
Glycerophospholipid biosynthesis pathway
REACT_188643
Phospholipid metabolism pathway
KEGG
mmu00561
Glycerolipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_121122
Acyl chain remodeling of DAG and TAG pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_121401
Glycerophospholipid biosynthesis pathway
REACT_120870
Phospholipid metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00561
Glycerolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q91WW7
TrEMBL E9QNZ9
UniProt Splice Variant
Entrez Gene 116939
UniGene Mm.390817 Mm.407427
RefSeq NM_054088
OMIM
CCDS CCDS37165
HPRD
IMGT
MGI ID MGI:2151796
MGI Symbol Pnpla3
EMBL AL626769 AY037763 BC028792
GenPept AAH28792 AAK68636
RNA Seq Atlas 116939

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca