Version 5.4
Mus musculus Protein: Pnpla3
Summary
InnateDB Protein IDBP-169090.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pnpla3
Protein Name patatin-like phospholipase domain containing 3
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000043826
InnateDB Gene IDBG-169088 (Pnpla3)
Protein Structure
UniProt Annotation
Function Multifunctional enzyme which has both triacylglycerol lipase and acylglycerol O-acyltransferase activities. {ECO:0000250}.
Subcellular Localization Membrane {ECO:0000269PubMed:11431482}; Single-pass membrane protein {ECO:0000269PubMed:11431482}.
Disease Associations
Tissue Specificity Restricted to adipose tissue. Expressed in inguinal and epididymal white adipose tissues and in interscapular brown adipose tissue. {ECO:0000269PubMed:11431482}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004623 phospholipase A2 activity
GO:0004806 triglyceride lipase activity
GO:0051264 mono-olein transacylation activity
GO:0051265 diolein transacylation activity
Biological Process
GO:0006629 lipid metabolic process
GO:0008152 metabolic process
GO:0019432 triglyceride biosynthetic process
GO:0019433 triglyceride catabolic process
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:2151796
InterPro IPR002641 Patatin/Phospholipase A2-related
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
PFAM PF01734
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91WW7
PhosphoSite PhosphoSite-
TrEMBL E9QNZ9
UniProt Splice Variant
Entrez Gene 116939
UniGene Mm.407427
RefSeq NP_473429
MGI ID
MGI Symbol Pnpla3
OMIM
CCDS CCDS37165
HPRD
IMGT
EMBL AL626769 AY037763 BC028792
GenPept AAH28792 AAK68636

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca