|Mus musculus Gene: Cstb|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||cystatin B|
|Useful resources||Stemformatics EHFPI ImmGen|
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000160213:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 10:78425670-78427619|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
|Pathway Predictions based on Human Orthology Data|
|UniProt Splice Variant|
|EMBL||AK002403 AK151205 BC056170 U59807|
|GenPept||AAC52851 AAH56170 BAB22074 BAE30202|
|RNA Seq Atlas||13014|