Version 5.4
Mus musculus Protein: Cstb
Summary
InnateDB Protein IDBP-169102.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cstb
Protein Name cystatin B
Synonyms AA960480; Stfb;
Species Mus musculus
Ensembl Protein ENSMUSP00000005185
InnateDB Gene IDBG-169100 (Cstb)
Protein Structure
UniProt Annotation
Function This is an intracellular thiol proteinase inhibitor.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity Widely expressed. Highest expression in heart, liver and kidney. Lower levels in brain, lung and skeletal muscle. Lowest levels in spleen and testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0004869 cysteine-type endopeptidase inhibitor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0008344 adult locomotory behavior
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
GO:0042981 regulation of apoptotic process
GO:0045861 negative regulation of proteolysis
Cellular Component
GO:0005615 extracellular space
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:109514
InterPro IPR000010 Proteinase inhibitor I25, cystatin
IPR001713 Proteinase inhibitor I25A, stefin A
PFAM PF00031
PRINTS PR00295
PIRSF
SMART SM00043
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q62426
PhosphoSite PhosphoSite-Q62426
TrEMBL
UniProt Splice Variant
Entrez Gene 13014
UniGene
RefSeq NP_031819
MGI ID
MGI Symbol Cstb
OMIM
CCDS CCDS23964
HPRD
IMGT
EMBL AK002403 AK151205 BC056170 U59807
GenPept AAC52851 AAH56170 BAB22074 BAE30202

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca