Homo sapiens Gene: GNA15
Summary
InnateDB Gene IDBG-16917.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GNA15
Gene Name guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Synonyms GNA16;
Species Homo sapiens
Ensembl Gene ENSG00000060558
Encoded Proteins
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:3136193-3163769
Strand Forward strand
Band p13.3
Transcripts
ENST00000262958 ENSP00000262958
ENST00000592455 ENSP00000467256
ENST00000586082
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001664 G-protein coupled receptor binding
GO:0003924 GTPase activity
GO:0004871 signal transducer activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0046872 metal ion binding
Biological Process
GO:0006184 GTP catabolic process
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
GO:0007596 blood coagulation
GO:0030168 platelet activation
GO:0060158 phospholipase C-activating dopamine receptor signaling pathway
Cellular Component
GO:0005834 heterotrimeric G-protein complex
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Integration of energy metabolism pathway
Thrombin signalling through proteinase activated receptors (PARs) pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G alpha (q) signalling events pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Acetylcholine regulates insulin secretion pathway
Free fatty acids regulate insulin secretion pathway
Thromboxane signalling through TP receptor pathway
ADP signalling through P2Y purinoceptor 1 pathway
Regulation of insulin secretion pathway
Metabolism pathway
Signal amplification pathway
Hemostasis pathway
KEGG
Calcium signaling pathway pathway
Chagas disease (American trypanosomiasis) pathway
Amoebiasis pathway
INOH
PID BIOCARTA
Fmlp induced chemokine gene expression in hmc-1 cells [Biocarta view]
PID NCI
IL8- and CXCR2-mediated signaling events
IL8- and CXCR1-mediated signaling events
Cross-References
SwissProt
TrEMBL K7EP74
UniProt Splice Variant
Entrez Gene 2769
UniGene Hs.73797
RefSeq NM_002068
HUGO HGNC:4383
OMIM 139314
CCDS CCDS12104
HPRD 00760
IMGT
EMBL AC005262 AC005264
GenPept
RNA Seq Atlas 2769