InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: S1PR4

Summary

InnateDB Gene

IDBG-16962.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S1PR4

Gene Name

sphingosine-1-phosphate receptor 4

Synonyms

EDG6; LPC1; S1P4; SLP4

Species

Homo sapiens

Ensembl Gene

ENSG00000125910

Encoded Proteins

IDBP-16964

sphingosine-1-phosphate receptor 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the endothelial differentiation, G-protein-coupled (EDG)) receptor gene family. EDG receptors bind lysophospholipids or lysosphingolipids as ligands, and are involved in cell signalling in many different cell types. This EDG receptor gene is intronless and is specifically expressed in the lymphoid tissue. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:3172346-3180332

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000246115	ENSP00000246115
ENST00000591346

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008289	lipid binding
GO:0038036	sphingosine-1-phosphate receptor activity

Biological Process

GO:0003376	sphingosine-1-phosphate signaling pathway
GO:0006955	immune response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007204	positive regulation of cytosolic calcium ion concentration