Version 5.4
Mus musculus Gene: Prkaa2
Summary
InnateDB Gene IDBG-169837.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Prkaa2
Gene Name protein kinase, AMP-activated, alpha 2 catalytic subunit
Synonyms 2310008I11Rik; A830082D05; AMPKalpha2
Species Mus musculus
Ensembl Gene ENSMUSG00000028518
Encoded Proteins
IDBP-169839
protein kinase, AMP-activated, alpha 2 catalytic subunit
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162409:
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:105029874-105109890
Strand Reverse strand
Band C6
Transcripts
ENSMUST00000030243 ENSMUSP00000030243
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 45 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004679 AMP-activated protein kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0009378 four-way junction helicase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0035174 histone serine kinase activity
GO:0046872 metal ion binding
GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
GO:0050405 [acetyl-CoA carboxylase] kinase activity
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006633 fatty acid biosynthetic process
GO:0006695 cholesterol biosynthetic process
GO:0006914 autophagy
GO:0006950 response to stress
GO:0008610 lipid biosynthetic process
GO:0010508 positive regulation of autophagy
GO:0016055 Wnt signaling pathway
GO:0031669 cellular response to nutrient levels
GO:0032007 negative regulation of TOR signaling
GO:0035404 histone-serine phosphorylation
GO:0042149 cellular response to glucose starvation
GO:0042593 glucose homeostasis
GO:0042752 regulation of circadian rhythm
GO:0043066 negative regulation of apoptotic process
GO:0045821 positive regulation of glycolytic process
GO:0048511 rhythmic process
GO:0055089 fatty acid homeostasis
GO:2000505 regulation of energy homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0009379 Holliday junction helicase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000162409
View Gene Order
ENSBTAG00000018747
Not yet available
Pathways
NETPATH
REACTOME
REACT_224594
Organelle biogenesis and maintenance pathway
REACT_256522
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_220701
Regulation of AMPK activity via LKB1 pathway
REACT_240250
Signaling by Insulin receptor pathway
REACT_217323
Integration of energy metabolism pathway
REACT_209837
Membrane Trafficking pathway
REACT_188937
Metabolism pathway
REACT_204167
Energy dependent regulation of mTOR by LKB1-AMPK pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_259732
Insulin receptor signalling cascade pathway
REACT_188215
IRS-related events triggered by IGF1R pathway
REACT_188218
IGF1R signaling cascade pathway
REACT_188219
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_257725
Regulation of Rheb GTPase activity by AMPK pathway
REACT_240139
PI3K Cascade pathway
REACT_250379
AMPK inhibits chREBP transcriptional activation activity pathway
REACT_257268
Import of palmitoyl-CoA into the mitochondrial matrix pathway
REACT_243154
IRS-related events pathway
REACT_242206
IRS-mediated signalling pathway
REACT_188257
Signal Transduction pathway
REACT_211261
Mitochondrial biogenesis pathway
REACT_255725
mTOR signalling pathway
REACT_256714
PKB-mediated events pathway
REACT_199054
Translocation of GLUT4 to the plasma membrane pathway
REACT_205688
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
KEGG
mmu04140
Regulation of autophagy pathway
mmu04910
Insulin signaling pathway pathway
mmu04150
mTOR signaling pathway pathway
mmu04920
Adipocytokine signaling pathway pathway
mmu04710
Circadian rhythm pathway
mmu05410
Hypertrophic cardiomyopathy (HCM) pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_21
RANKL pathway
NetPath_22
Leptin pathway
NetPath_25
FSH pathway
REACTOME
REACT_21393
Regulation of Rheb GTPase activity by AMPK pathway
REACT_21285
Regulation of AMPK activity via LKB1 pathway
REACT_6838
mTOR signalling pathway
REACT_976
PI3K Cascade pathway
REACT_498
Signaling by Insulin receptor pathway
REACT_150203
IRS-related events triggered by IGF1R pathway
REACT_150359
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
REACT_11082
Import of palmitoyl-CoA into the mitochondrial matrix pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_1988
AMPK inhibits chREBP transcriptional activation activity pathway
REACT_1505
Integration of energy metabolism pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_21387
Energy dependent regulation of mTOR by LKB1-AMPK pathway
REACT_200751
Organelle biogenesis and maintenance pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_456
PKB-mediated events pathway
REACT_200686
Activation of PPARGC1A (PGC-1alpha) by phosphorylation pathway
REACT_200788
Mitochondrial biogenesis pathway
REACT_111102
Signal Transduction pathway
REACT_332
IRS-mediated signalling pathway
REACT_1195
Insulin receptor signalling cascade pathway
REACT_762
IRS-related events pathway
REACT_150210
IGF1R signaling cascade pathway
REACT_111217
Metabolism pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04150
mTOR signaling pathway pathway
hsa04140
Regulation of autophagy pathway
hsa04710
Circadian rhythm pathway
hsa04910
Insulin signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa05410
Hypertrophic cardiomyopathy (HCM) pathway
INOH
INOH website
IL-7 signaling pathway
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
Insulin receptor signaling pathway
INOH website
VEGF signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.401772 Mm.402845 Mm.48638
RefSeq NM_178143 XM_006502651
OMIM
CCDS CCDS18416
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca