Mus musculus Gene: Psenen
Summary
InnateDB Gene IDBG-170124.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psenen
Gene Name presenilin enhancer 2 homolog (C. elegans)
Synonyms 1700023M09Rik; Pen-2;
Species Mus musculus
Ensembl Gene ENSMUSG00000036835
Encoded Proteins
presenilin enhancer 2 homolog (C. elegans)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000205155:
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:30561868-30563184
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000043898 ENSMUSP00000044682
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006509 membrane protein ectodomain proteolysis
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0016485 protein processing
GO:0043085 positive regulation of catalytic activity
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Nuclear signaling by ERBB4 pathway
Disease pathway
Signaling by ERBB4 pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
EPH-ephrin mediated repulsion of cells pathway
Signaling by NOTCH1 pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Signaling by NOTCH2 pathway
Signaling by NOTCH3 pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
EPH-Ephrin signaling pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by NOTCH4 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Axon guidance pathway
Signalling by NGF pathway
Developmental Biology pathway
Regulated proteolysis of p75NTR pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
NRIF signals cell death from the nucleus pathway
Signaling by NOTCH pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
KEGG
Notch signaling pathway pathway
Alzheimer's disease pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Notch pathway
REACTOME
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Signaling by NOTCH1 in Cancer pathway
Signaling by ERBB4 pathway
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
Axon guidance pathway
p75 NTR receptor-mediated signalling pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signaling by NOTCH4 pathway
Signal Transduction pathway
Regulated proteolysis of p75NTR pathway
Signaling by NOTCH2 pathway
Signaling by NOTCH3 pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
NRIF signals cell death from the nucleus pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
EPH-ephrin mediated repulsion of cells pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
EPH-Ephrin signaling pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Nuclear signaling by ERBB4 pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
Disease pathway
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Signaling by NOTCH pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by ERBB4 pathway
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
NRIF signals cell death from the nucleus pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
EPH-Ephrin signaling pathway
Signaling by NOTCH3 pathway
Signaling by NOTCH1 in Cancer pathway
Signal Transduction pathway
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
Axon guidance pathway
Signaling by NOTCH1 pathway
EPH-ephrin mediated repulsion of cells pathway
Signalling by NGF pathway
Regulated proteolysis of p75NTR pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH4 pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
p75 NTR receptor-mediated signalling pathway
Nuclear signaling by ERBB4 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Signaling by NOTCH2 pathway
Disease pathway
Developmental Biology pathway
KEGG
Notch signaling pathway pathway
Alzheimer's disease pathway
INOH
PID BIOCARTA
PID NCI
Presenilin action in Notch and Wnt signaling
p75(NTR)-mediated signaling
Syndecan-3-mediated signaling events
Notch signaling pathway
Cross-References
SwissProt Q9CQR7
TrEMBL
UniProt Splice Variant
Entrez Gene 66340
UniGene Mm.467283 Mm.467301
RefSeq NM_025498
OMIM
CCDS CCDS21099
HPRD
IMGT
MGI ID MGI:1913590
MGI Symbol Psenen
EMBL AK002440 AK006284 AK007621 BC024347 BC081443
GenPept AAH24347 AAH81443 BAB22102 BAB24503 BAB25141
RNA Seq Atlas 66340