InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PSENEN

Summary

InnateDB Gene

IDBG-45229.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSENEN

Gene Name

presenilin enhancer 2 homolog (C. elegans)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000205155

Encoded Proteins

IDBP-45231

presenilin enhancer 2 homolog (C. elegans)

IDBP-761307

IDBP-765703

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:35745114-35747519

Strand

Forward strand

Band

q13.12

Transcripts

ENST00000222266	ENSP00000222266
ENST00000591949	ENSP00000468593
ENST00000587708	ENSP00000468411

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006509	membrane protein ectodomain proteolysis
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0016485	protein processing
GO:0031293	membrane protein intracellular domain proteolysis
GO:0042987	amyloid precursor protein catabolic process
GO:0043065	positive regulation of apoptotic process
GO:0043085	positive regulation of catalytic activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0032580	Golgi cisterna membrane