Homo sapiens Gene: NUP155
Summary
InnateDB Gene IDBG-17015.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUP155
Gene Name nucleoporin 155kDa
Synonyms ATFB15; N155;
Species Homo sapiens
Ensembl Gene ENSG00000113569
Encoded Proteins
nucleoporin 155kDa
nucleoporin 155kDa
nucleoporin 155kDa
nucleoporin 155kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Nucleoporins are the main components of the nuclear pore complex (NPC) of eukaryotic cells. They are involved in the bidirectional trafficking of molecules, especially mRNAs and proteins, between the nucleus and the cytoplasm. The protein encoded by this gene does not contain the typical FG repeat sequences found in most vertebrate nucleoporins. Two protein isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:37288137-37371181
Strand Reverse strand
Band p13.2
Transcripts
ENST00000381843 ENSP00000371265
ENST00000231498 ENSP00000231498
ENST00000508182
ENST00000502533
ENST00000513532 ENSP00000422019
ENST00000515054
ENST00000507233
ENST00000507675 ENSP00000423484
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0017056 structural constituent of nuclear pore
Biological Process
GO:0000278 mitotic cell cycle
GO:0005975 carbohydrate metabolic process
GO:0006406 mRNA export from nucleus
GO:0006606 protein import into nucleus
GO:0006913 nucleocytoplasmic transport
GO:0006998 nuclear envelope organization
GO:0007077 mitotic nuclear envelope disassembly
GO:0008645 hexose transport
GO:0010827 regulation of glucose transport
GO:0015758 glucose transport
GO:0016032 viral process
GO:0019221 cytokine-mediated signaling pathway
GO:0044281 small molecule metabolic process
GO:0055085 transmembrane transport
GO:0086014 atrial cardiac muscle cell action potential
Cellular Component
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0016020 membrane
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Transmembrane transport of small molecules pathway
Influenza Infection pathway
Interactions of Vpr with host cellular proteins pathway
Vpr-mediated nuclear import of PICs pathway
Myoclonic epilepsy of Lafora pathway
Antiviral mechanism by IFN-stimulated genes pathway
Glucose transport pathway
Hexose transport pathway
Cytokine Signaling in Immune system pathway
Metabolism of carbohydrates pathway
Late Phase of HIV Life Cycle pathway
Viral Messenger RNA Synthesis pathway
Transcriptional regulation by small RNAs pathway
Nuclear Pore Complex (NPC) Disassembly pathway
Influenza Viral RNA Transcription and Replication pathway
Interferon Signaling pathway
Cell Cycle pathway
Immune System pathway
Regulation of Glucokinase by Glucokinase Regulatory Protein pathway
M Phase pathway
HIV Life Cycle pathway
Mitotic Prophase pathway
Rev-mediated nuclear export of HIV RNA pathway
Cell Cycle, Mitotic pathway
HIV Infection pathway
ISG15 antiviral mechanism pathway
Influenza Life Cycle pathway
Nuclear import of Rev protein pathway
Metabolism pathway
Host Interactions of HIV factors pathway
SLC-mediated transmembrane transport pathway
Interactions of Rev with host cellular proteins pathway
Gene Expression pathway
Nuclear Envelope Breakdown pathway
Disease pathway
Glycogen storage diseases pathway
Regulatory RNA pathways pathway
KEGG
RNA transport pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.547696 Hs.633161
RefSeq NM_001278312 NM_004298 NM_153485
HUGO
OMIM
CCDS CCDS3921 CCDS43310 CCDS64142
HPRD 05984
IMGT
EMBL
GenPept
RNA Seq Atlas