Version 5.4
Mus musculus Gene: Bcl11b
Summary
InnateDB Gene IDBG-170175.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bcl11b
Gene Name B cell leukemia/lymphoma 11B
Synonyms 9130430L19Rik; AI604821; B630002E05Rik; BCL-11B; Ctip2; Rit1
Species Mus musculus
Ensembl Gene ENSMUSG00000048251
Encoded Proteins
IDBP-170177
B-cell leukemia/lymphoma 11B
IDBP-261427
B-cell leukemia/lymphoma 11B
IDBP-261429
B-cell leukemia/lymphoma 11B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25964371
Bcl11b, a transcription factor essential in T cell lineage commitment and maintenance, is specifically expressed in progenitors committed to the group 2 innate lymphoid cells (ILC2) lineage and is required for ILC2 development.
PMID 25964370
Bcl11b is a factor in the differentiation of group 2 innate lymphoid cells (ILC2s).
PMID 26231117
Bcl11b sustains the genetic and functional programs, as well as lineage fidelity, of mature type 2 innate lymphoid cells.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127152:
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:107910403-108003602
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000066060 ENSMUSP00000068258
ENSMUST00000109891 ENSMUSP00000105517
ENSMUST00000109887 ENSMUSP00000105513
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 3 [view]
Protein-DNA 10 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0003334 keratinocyte development
GO:0003382 epithelial cell morphogenesis
GO:0006351 transcription, DNA-templated
GO:0007409 axonogenesis
GO:0008285 negative regulation of cell proliferation
GO:0009791 post-embryonic development
GO:0010468 regulation of gene expression
GO:0010837 regulation of keratinocyte proliferation
GO:0019216 regulation of lipid metabolic process
GO:0021773 striatal medium spiny neuron differentiation
GO:0021953 central nervous system neuron differentiation
GO:0031077 post-embryonic camera-type eye development
GO:0033077 T cell differentiation in thymus
GO:0033153 T cell receptor V(D)J recombination
GO:0042475 odontogenesis of dentin-containing tooth
GO:0043066 negative regulation of apoptotic process
GO:0043368 positive T cell selection
GO:0043588 skin development
GO:0045087 innate immune response (InnateDB)
GO:0045664 regulation of neuron differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0046632 alpha-beta T cell differentiation
GO:0048538 thymus development
GO:0071678 olfactory bulb axon guidance
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000127152
View Gene Order
ENSBTAG00000018019
Not yet available
Cross-References
SwissProt Q99PV8
TrEMBL Q3TEG9
UniProt Splice Variant
Entrez Gene 58208
UniGene Mm.392694 Mm.400651 Mm.418309
RefSeq NM_021399 NM_001079883 NM_001286343 XM_006516110 XM_006516111 XM_006516112 XM_006516115 XM_006516116
OMIM
CCDS CCDS36552 CCDS36553 CCDS70419
HPRD
IMGT
MGI ID MGI:1929913
MGI Symbol Bcl11b
EMBL AB043551 AB043553 AB043583 AF186019 AK088588 AK169655 BC019503
GenPept AAF63683 AAH19503 BAB32728 BAB32729 BAB32730 BAC40438 BAE41279
RNA Seq Atlas 58208

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca