Version 5.4
Mus musculus Gene: Pcsk9
Summary
InnateDB Gene IDBG-170186.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pcsk9
Gene Name proprotein convertase subtilisin/kexin type 9
Synonyms AI415265; AI747682; FH3; HCHOLA3; Narc1; PC9
Species Mus musculus
Ensembl Gene ENSMUSG00000044254
Encoded Proteins
IDBP-170190
proprotein convertase subtilisin/kexin type 9
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169174:
This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:106442329-106464329
Strand Reverse strand
Band C7
Transcripts
ENSMUST00000049507 ENSMUSP00000055757
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0019871 sodium channel inhibitor activity
GO:0030169 low-density lipoprotein particle binding
GO:0034185 apolipoprotein binding
GO:0034189 very-low-density lipoprotein particle binding
GO:0034190 apolipoprotein receptor binding
GO:0043621 protein self-association
GO:0044822 poly(A) RNA binding
GO:0050750 low-density lipoprotein particle receptor binding
GO:0070326 very-low-density lipoprotein particle receptor binding
Biological Process
GO:0001822 kidney development
GO:0001889 liver development
GO:0001920 negative regulation of receptor recycling
GO:0002092 positive regulation of receptor internalization
GO:0006508 proteolysis
GO:0006641 triglyceride metabolic process
GO:0006644 phospholipid metabolic process
GO:0006915 apoptotic process
GO:0007041 lysosomal transport
GO:0008203 cholesterol metabolic process
GO:0009267 cellular response to starvation
GO:0010469 regulation of receptor activity
GO:0010989 negative regulation of low-density lipoprotein particle clearance
GO:0016485 protein processing
GO:0016540 protein autoprocessing
GO:0022008 neurogenesis
GO:0030182 neuron differentiation
GO:0032799 low-density lipoprotein receptor particle metabolic process
GO:0032802 low-density lipoprotein particle receptor catabolic process
GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process
GO:0032869 cellular response to insulin stimulus
GO:0042157 lipoprotein metabolic process
GO:0042632 cholesterol homeostasis
GO:0043523 regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005791 rough endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0030134 ER to Golgi transport vesicle
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000169174
View Gene Order
Pathways
NETPATH
REACTOME
REACT_248921
Signalling by NGF pathway
REACT_188257
Signal Transduction pathway
REACT_206713
NGF processing pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q80W65
TrEMBL
UniProt Splice Variant
Entrez Gene 100102
UniGene Mm.133268
RefSeq NM_153565
OMIM
CCDS CCDS18418
HPRD
IMGT
MGI ID MGI:2140260
MGI Symbol Pcsk9
EMBL AK149520 AL954352 AX207688 AY273821 BC038085
GenPept AAH38085 AAP31672 BAE28934 CAC60362 CAM15751
RNA Seq Atlas 100102

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca