Mus musculus Gene: Tspan6
Summary
InnateDB Gene IDBG-170366.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tspan6
Gene Name tetraspanin 6
Synonyms 6720473L21Rik; AI316786; T245; Tm4sf; Tm4sf6; TSPAN-6;
Species Mus musculus
Ensembl Gene ENSMUSG00000067377
Encoded Proteins
tetraspanin 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000000003:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The protein encoded by this gene is a cell surface glycoprotein and is highly similar in sequence to the transmembrane 4 superfamily member 2 protein. It functions as a negative regulator of retinoic acid-inducible gene I-like receptor-mediated immune signaling via its interaction with the mitochondrial antiviral signaling-centered signalosome. This gene uses alternative polyadenylation sites, and multiple transcript variants result from alternative splicing. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome X:133891068-133898429
Strand Reverse strand
Band E3
Transcripts
ENSMUST00000087557 ENSMUSP00000084838
ENSMUST00000176641 ENSMUSP00000135626
ENSMUST00000176718 ENSMUSP00000135005
ENSMUST00000177468
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0039532 negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1901223 negative regulation of NIK/NF-kappaB signaling
Cellular Component
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL H3BJJ0 H3BL26 Q99L96
UniProt Splice Variant
Entrez Gene 56496
UniGene Mm.402063 Mm.406163 Mm.46701
RefSeq NM_019656
OMIM
CCDS CCDS30387
HPRD
IMGT
MGI ID MGI:1926264
MGI Symbol Tspan6
EMBL AK146673 AK149204 AK167384 AL691421 BC003733 BC110314 CH466598
GenPept AAH03733 AAI10315 BAE27349 BAE28764 BAE39476 EDL20414
RNA Seq Atlas 56496