Mus musculus Gene: Psmb8
Summary
InnateDB Gene IDBG-170702.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psmb8
Gene Name proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
Synonyms Lmp-7; Lmp7;
Species Mus musculus
Ensembl Gene ENSMUSG00000024338
Encoded Proteins
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PSMB8 (LMP7) inhibits phagocytosis and enhances susceptibility of red blood cells to malarial parasites.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000204264:
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:34197721-34201454
Strand Forward strand
Band B1
Transcripts
ENSMUST00000025196 ENSMUSP00000025196
ENSMUST00000173441 ENSMUSP00000134664
ENSMUST00000172960
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004298 threonine-type endopeptidase activity
GO:0005515 protein binding
Biological Process
GO:0019882 antigen processing and presentation
GO:0045087 innate immune response (InnateDB)
GO:0045444 fat cell differentiation
GO:0051603 proteolysis involved in cellular protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0070062 extracellular vesicular exosome
GO:1990111 spermatoproteasome complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
p53-Independent G1/S DNA damage checkpoint pathway
Autodegradation of the E3 ubiquitin ligase COP1 pathway
Apoptosis pathway
Signaling by the B Cell Receptor (BCR) pathway
Cell Cycle, Mitotic pathway
Class I MHC mediated antigen processing & presentation pathway
Disease pathway
Synthesis of DNA pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Ubiquitin-dependent degradation of Cyclin D1 pathway
Signaling by Wnt pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Separation of Sister Chromatids pathway
Hedgehog 'off' state pathway
DNA Replication pathway
Signaling by WNT in cancer pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
Switching of origins to a post-replicative state pathway
degradation of DVL pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Degradation of beta-catenin by the destruction complex pathway
beta-catenin independent WNT signaling pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
p53-Independent DNA Damage Response pathway
p53-Dependent G1 DNA Damage Response pathway
p53-Dependent G1/S DNA damage checkpoint pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
AMER1 mutants destabilize the destruction complex pathway
Cell Cycle pathway
Stabilization of p53 pathway
Metabolism pathway
APC/C-mediated degradation of cell cycle proteins pathway
Immune System pathway
M Phase pathway
Cell Cycle Checkpoints pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
Hedgehog ligand biogenesis pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
ER-Phagosome pathway pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Processing-defective Hh variants abrogate ligand secretion pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
APC truncation mutants have impaired AXIN binding pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Cross-presentation of soluble exogenous antigens (endosomes) pathway
Regulation of DNA replication pathway
Metabolism of amino acids and derivatives pathway
Orc1 removal from chromatin pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
M/G1 Transition pathway
PCP/CE pathway pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Regulation of Apoptosis pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Activation of NF-kappaB in B cells pathway
Degradation of GLI2 by the proteasome pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Regulation of mitotic cell cycle pathway
APC/C:Cdc20 mediated degradation of Securin pathway
G1/S DNA Damage Checkpoints pathway
Degradation of GLI1 by the proteasome pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Hh ligand biogenesis disease pathway
AXIN missense mutants destabilize the destruction complex pathway
TCF dependent signaling in response to WNT pathway
GLI3 is processed to GLI3R by the proteasome pathway
Mitotic Metaphase and Anaphase pathway
G1/S Transition pathway
Removal of licensing factors from origins pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Regulation of ornithine decarboxylase (ODC) pathway
Antigen processing-Cross presentation pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
Mitotic G1-G1/S phases pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
TCF7L2 mutants don't bind CTBP pathway
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
Gene Expression pathway
Adaptive Immune System pathway
truncations of AMER1 destabilize the destruction complex pathway
Ubiquitin-dependent degradation of Cyclin D pathway
Signaling by Hedgehog pathway
degradation of AXIN pathway
Asymmetric localization of PCP proteins pathway
Cyclin E associated events during G1/S transition pathway
Signal Transduction pathway
truncated APC mutants destabilize the destruction complex pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
DNA Replication Pre-Initiation pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
Mitotic Anaphase pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Assembly of the pre-replicative complex pathway
S Phase pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
Proteasome pathway
INOH
TGF-beta signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
DNA Replication pathway
PCP/CE pathway pathway
truncated APC mutants destabilize the destruction complex pathway
p53-Dependent G1/S DNA damage checkpoint pathway
p53-Independent G1/S DNA damage checkpoint pathway
Processing-defective Hh variants abrogate ligand secretion pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
APC truncation mutants are not K63 polyubiquitinated pathway
Signaling by Hedgehog pathway
AMER1 mutants destabilize the destruction complex pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Synthesis of DNA pathway
Signaling by WNT in cancer pathway
APC/C-mediated degradation of cell cycle proteins pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
beta-catenin independent WNT signaling pathway
AXIN missense mutants destabilize the destruction complex pathway
Vif-mediated degradation of APOBEC3G pathway
Regulation of mitotic cell cycle pathway
APC/C:Cdc20 mediated degradation of Securin pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Signaling by Wnt pathway
Interferon alpha/beta signaling pathway
Mitotic G1-G1/S phases pathway
Cytokine Signaling in Immune system pathway
S Phase pathway
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Stabilization of p53 pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of GLI2 by the proteasome pathway
degradation of DVL pathway
GLI3 is processed to GLI3R by the proteasome pathway
Autodegradation of the E3 ubiquitin ligase COP1 pathway
ER-Phagosome pathway pathway
Degradation of beta-catenin by the destruction complex pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Degradation of GLI1 by the proteasome pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Apoptosis pathway
Signal Transduction pathway
Interferon Signaling pathway
Separation of Sister Chromatids pathway
Hedgehog 'off' state pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
Hh ligand biogenesis disease pathway
Ubiquitin-dependent degradation of Cyclin D pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
Cell Cycle pathway
Antigen processing-Cross presentation pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
Activation of NF-kappaB in B cells pathway
Adaptive Immune System pathway
Metabolism of amino acids and derivatives pathway
Removal of licensing factors from origins pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Regulation of ornithine decarboxylase (ODC) pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
p53-Dependent G1 DNA Damage Response pathway
truncations of AMER1 destabilize the destruction complex pathway
M Phase pathway
Cyclin E associated events during G1/S transition pathway
Hedgehog ligand biogenesis pathway
Mitotic Anaphase pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
TCF dependent signaling in response to WNT pathway
Switching of origins to a post-replicative state pathway
Asymmetric localization of PCP proteins pathway
Ubiquitin-dependent degradation of Cyclin D1 pathway
M/G1 Transition pathway
degradation of AXIN pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Cross-presentation of soluble exogenous antigens (endosomes) pathway
Orc1 removal from chromatin pathway
Cell Cycle, Mitotic pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
TCF7L2 mutants don't bind CTBP pathway
HIV Infection pathway
Class I MHC mediated antigen processing & presentation pathway
CDT1 association with the CDC6:ORC:origin complex pathway
p53-Independent DNA Damage Response pathway
G1/S DNA Damage Checkpoints pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Metabolism pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
Host Interactions of HIV factors pathway
Regulation of DNA replication pathway
Signaling by the B Cell Receptor (BCR) pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
Vpu mediated degradation of CD4 pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Regulation of Apoptosis pathway
Gene Expression pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
Disease pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Assembly of the pre-replicative complex pathway
Cell Cycle Checkpoints pathway
Mitotic Metaphase and Anaphase pathway
APC truncation mutants have impaired AXIN binding pathway
Degradation of GLI1 by the proteasome pathway
Regulation of Apoptosis pathway
ER-Phagosome pathway pathway
Signaling by Wnt pathway
Signaling by WNT in cancer pathway
S Phase pathway
Hedgehog ligand biogenesis pathway
S33 mutants of beta-catenin aren't phosphorylated pathway
CDT1 association with the CDC6:ORC:origin complex pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Mitotic G1-G1/S phases pathway
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
DNA Replication Pre-Initiation pathway
Metabolism of amino acids and derivatives pathway
GLI3 is processed to GLI3R by the proteasome pathway
Stabilization of p53 pathway
M Phase pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
DNA Replication pathway
p53-Independent G1/S DNA damage checkpoint pathway
Assembly of the pre-replicative complex pathway
Separation of Sister Chromatids pathway
G1/S DNA Damage Checkpoints pathway
G1/S Transition pathway
TCF dependent signaling in response to WNT pathway
Class I MHC mediated antigen processing & presentation pathway
Regulation of DNA replication pathway
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Orc1 removal from chromatin pathway
S37 mutants of beta-catenin aren't phosphorylated pathway
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Anaphase pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Gene Expression pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Asymmetric localization of PCP proteins pathway
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
Immune System pathway
Cell Cycle, Mitotic pathway
truncations of AMER1 destabilize the destruction complex pathway
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
Ubiquitin-dependent degradation of Cyclin D pathway
XAV939 inhibits tankyrase, stabilizing AXIN pathway
AUF1 (hnRNP D0) destabilizes mRNA pathway
Synthesis of DNA pathway
Signaling by the B Cell Receptor (BCR) pathway
Degradation of GLI2 by the proteasome pathway
Cell Cycle pathway
Signal Transduction pathway
Regulation of ornithine decarboxylase (ODC) pathway
degradation of AXIN pathway
AXIN missense mutants destabilize the destruction complex pathway
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
Hedgehog 'off' state pathway
SCF-beta-TrCP mediated degradation of Emi1 pathway
Cyclin E associated events during G1/S transition pathway
misspliced GSK3beta mutants stabilize beta-catenin pathway
Autodegradation of the E3 ubiquitin ligase COP1 pathway
beta-catenin independent WNT signaling pathway
p53-Independent DNA Damage Response pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Regulation of mitotic cell cycle pathway
Cross-presentation of soluble exogenous antigens (endosomes) pathway
PCP/CE pathway pathway
M/G1 Transition pathway
TCF7L2 mutants don't bind CTBP pathway
p53-Dependent G1 DNA Damage Response pathway
Metabolism pathway
deletions in the AMER1 gene destabilize the destruction complex pathway
CDK-mediated phosphorylation and removal of Cdc6 pathway
AMER1 mutants destabilize the destruction complex pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
APC/C-mediated degradation of cell cycle proteins pathway
Processing-defective Hh variants abrogate ligand secretion pathway
Adaptive Immune System pathway
Signaling by Hedgehog pathway
RNF mutants show enhanced WNT signaling and proliferation pathway
Activation of NF-kappaB in B cells pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
degradation of DVL pathway
Ubiquitin-dependent degradation of Cyclin D1 pathway
S45 mutants of beta-catenin aren't phosphorylated pathway
APC truncation mutants are not K63 polyubiquitinated pathway
p53-Dependent G1/S DNA damage checkpoint pathway
Hh ligand biogenesis disease pathway
Removal of licensing factors from origins pathway
Cell Cycle Checkpoints pathway
Disease pathway
Degradation of beta-catenin by the destruction complex pathway
Antigen processing-Cross presentation pathway
Switching of origins to a post-replicative state pathway
Apoptosis pathway
T41 mutants of beta-catenin aren't phosphorylated pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
truncated APC mutants destabilize the destruction complex pathway
APC/C:Cdc20 mediated degradation of Securin pathway
KEGG
Proteasome pathway
INOH
TGF-beta signaling pathway
PID BIOCARTA
Antigen processing and presentation [Biocarta view]
PID NCI
Cross-References
SwissProt P28063
TrEMBL
UniProt Splice Variant
Entrez Gene 16913
UniGene Mm.180191 Mm.484878
RefSeq NM_010724
OMIM
CCDS CCDS50073
HPRD
IMGT
MGI ID MGI:1346527
MGI Symbol Psmb8
EMBL AF027865 AK031801 AK050627 AK146182 AK150674 AK159971 BC013785 BC051450 L11145 U22031 U22032 U22033 U22034 U22035 X64449 Z21847
GenPept AAA75033 AAA75034 AAA75035 AAA75036 AAA75037 AAB46392 AAB81532 AAH13785 AAH51450 BAC27555 BAE20682 BAE26960 BAE29756 BAE35524 CAA45779 CAA45780 CAB60065
RNA Seq Atlas 16913