Version 5.4
Mus musculus Protein: Psmb8
Summary
InnateDB Protein IDBP-170704.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psmb8
Protein Name proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)
Synonyms Lmp-7; Lmp7;
Species Mus musculus
Ensembl Protein ENSMUSP00000025196
InnateDB Gene IDBG-170702 (Psmb8)
Protein Structure
UniProt Annotation
Function The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. May be involved in the inflammatory response pathway. Required for adipocyte differentiation. {ECO:0000269PubMed:21881205, ECO:0000269PubMed:22341445, ECO:0000269PubMed:8066463}.
Subcellular Localization Cytoplasm {ECO:0000255PROSITE- ProRule:PRU00809}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Detected in liver (at protein level). Expressed in spleen, thymus, lung, liver, heart and, at a very low level, in kidney. Not expressed in brain nor testis. {ECO:0000269PubMed:22341445, ECO:0000269PubMed:8406612}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 36 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004298 threonine-type endopeptidase activity
GO:0005515 protein binding
Biological Process
GO:0019882 antigen processing and presentation
GO:0045087 innate immune response (InnateDB)
GO:0045444 fat cell differentiation
GO:0051603 proteolysis involved in cellular protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0070062 extracellular vesicular exosome
GO:1990111 spermatoproteasome complex
Protein Structure and Domains
PDB ID MGI:1346527
InterPro IPR000243 Peptidase T1A, proteasome beta-subunit
IPR001353 Proteasome, subunit alpha/beta
IPR029055 Nucleophile aminohydrolases, N-terminal
PFAM PF00227
PRINTS PR00141
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P28063
PhosphoSite PhosphoSite-P28063
TrEMBL
UniProt Splice Variant
Entrez Gene 16913
UniGene Mm.484878
RefSeq NP_034854
MGI ID 3UNH
MGI Symbol Psmb8
OMIM
CCDS CCDS50073
HPRD
IMGT
EMBL AF027865 AK031801 AK050627 AK146182 AK150674 AK159971 BC013785 BC051450 L11145 U22031 U22032 U22033 U22034 U22035 X64449 Z21847
GenPept AAA75033 AAA75034 AAA75035 AAA75036 AAA75037 AAB46392 AAB81532 AAH13785 AAH51450 BAC27555 BAE20682 BAE26960 BAE29756 BAE35524 CAA45779 CAA45780 CAB60065

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca