InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tap2

Summary

InnateDB Gene

IDBG-170752.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tap2

Gene Name

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Synonyms

ABC18; Abcb3; AI462429; APT2; Ham-2; Ham2; jas; MTP2; PSF2; RING11; Tap-2; Y1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024339

Encoded Proteins

IDBP-170754

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

IDBP-536168

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

IDBP-542364

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with Tap1 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in the human gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:34203527-34216321

Strand

Forward strand

Band

Transcripts

ENSMUST00000025197	ENSMUSP00000025197
ENSMUST00000138491	ENSMUSP00000118916
ENSMUST00000127543
ENSMUST00000131105	ENSMUSP00000118700
ENSMUST00000145528

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015197	peptide transporter activity
GO:0016887	ATPase activity
GO:0017111	nucleoside-triphosphatase activity
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0046978	TAP1 binding
GO:0046980	tapasin binding

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002237	response to molecule of bacterial origin
GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO:0002485	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
GO:0002489	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
GO:0002591	positive regulation of antigen processing and presentation of peptide antigen via MHC class I
GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0015031	protein transport
GO:0015833	peptide transport
GO:0055085	transmembrane transport