Homo sapiens Gene: TAP2
Summary
InnateDB Gene IDBG-81449.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TAP2
Gene Name transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Synonyms ABC18; ABCB3; APT2; D6S217E; PSF-2; PSF2; RING11;
Species Homo sapiens
Ensembl Gene ENSG00000204267
Encoded Proteins
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Jul 2008]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:32821833-32838780
Strand Reverse strand
Band p21.32
Transcripts
ENST00000374899 ENSP00000364034
ENST00000374897 ENSP00000364032
ENST00000464100
ENST00000485701
ENST00000620123 ENSP00000481712
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 16 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0015197 peptide transporter activity
GO:0015433 peptide antigen-transporting ATPase activity
GO:0016887 ATPase activity
GO:0023029 MHC class Ib protein binding
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0046978 TAP1 binding
GO:0046980 tapasin binding
Biological Process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002481 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO:0002485 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
GO:0002489 antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
GO:0002591 positive regulation of antigen processing and presentation of peptide antigen via MHC class I
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0019060 intracellular transport of viral protein in host cell
GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0046967 cytosol to ER transport
GO:0046968 peptide antigen transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
GO:0042825 TAP complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
ER-Phagosome pathway pathway
Antigen processing-Cross presentation pathway
Adaptive Immune System pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
ABC transporters pathway
Phagosome pathway
Antigen processing and presentation pathway
Primary immunodeficiency pathway
INOH
PID BIOCARTA
Antigen processing and presentation [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.502
RefSeq NM_000544 NM_001290043 NM_018833
HUGO
OMIM
CCDS CCDS4755
HPRD 01360
IMGT
EMBL
GenPept
RNA Seq Atlas