InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TAP2

Summary

InnateDB Gene

IDBG-81449.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAP2

Gene Name

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Synonyms

ABC18; ABCB3; APT2; D6S217E; PSF-2; PSF2; RING11

Species

Homo sapiens

Ensembl Gene

ENSG00000204267

Encoded Proteins

IDBP-81451

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

IDBP-81453

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

IDBP-813077

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Jul 2008]
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:32821833-32838780

Strand

Reverse strand

Band

p21.32

Transcripts

ENST00000374899	ENSP00000364034
ENST00000374897	ENSP00000364032
ENST00000464100
ENST00000485701
ENST00000620123	ENSP00000481712

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	16 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0015197	peptide transporter activity
GO:0015433	peptide antigen-transporting ATPase activity
GO:0016887	ATPase activity
GO:0023029	MHC class Ib protein binding
GO:0042626	ATPase activity, coupled to transmembrane movement of substances
GO:0046978	TAP1 binding
GO:0046980	tapasin binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002481	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
GO:0002485	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
GO:0002489	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
GO:0002591	positive regulation of antigen processing and presentation of peptide antigen via MHC class I
GO:0006200	ATP catabolic process
GO:0006810	transport
GO:0019060	intracellular transport of viral protein in host cell
GO:0019885	antigen processing and presentation of endogenous peptide antigen via MHC class I
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0046967	cytosol to ER transport
GO:0046968	peptide antigen transport
GO:0055085	transmembrane transport

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0042825	TAP complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024339

View Gene Order

ENSBTAG00000003038

Not yet available

Pathways

NETPATH

REACTOME

REACT_75795

Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway

REACT_111178

ER-Phagosome pathway pathway

REACT_111119

Antigen processing-Cross presentation pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

KEGG

hsa04612

Antigen processing and presentation pathway

hsa02010

ABC transporters pathway

hsa05340

Primary immunodeficiency pathway

hsa04145

Phagosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.502

RefSeq

NM_000544 NM_001290043 NM_018833

HUGO

OMIM

CCDS

CCDS4755

HPRD

01360

IMGT

EMBL

GenPept

RNA Seq Atlas