Version 5.4
Mus musculus Gene: Fstl3
Summary
InnateDB Gene IDBG-170833.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fstl3
Gene Name follistatin-like 3
Synonyms E030038F23Rik; Flrg
Species Mus musculus
Ensembl Gene ENSMUSG00000020325
Encoded Proteins
IDBP-170835
follistatin-like 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000070404:
Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:79777272-79782630
Strand Forward strand
Band C1
Transcripts
ENSMUST00000020575 ENSMUSP00000020575
ENSMUST00000170380
ENSMUST00000168798
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005515 protein binding
GO:0048185 activin binding
Biological Process
GO:0001503 ossification
GO:0001822 kidney development
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007283 spermatogenesis
GO:0008584 male gonad development
GO:0022409 positive regulation of cell-cell adhesion
GO:0030324 lung development
GO:0030325 adrenal gland development
GO:0030514 negative regulation of BMP signaling pathway
GO:0032926 negative regulation of activin receptor signaling pathway
GO:0045671 negative regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071248 cellular response to metal ion
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0030141 secretory granule
GO:0044306 neuron projection terminus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000070404
View Gene Order
ENSBTAG00000003018
Not yet available
Pathways
NETPATH
REACTOME
REACT_216258
Signaling by Activin pathway
REACT_196633
Antagonism of Activin by Follistatin pathway
REACT_188257
Signal Transduction pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150276
Antagonism of Activin by Follistatin pathway
REACT_150238
Signaling by Activin pathway
REACT_111102
Signal Transduction pathway
REACT_212890
Antagonism of Activin by Follistatin pathway
REACT_214353
Signal Transduction pathway
REACT_224587
Signaling by Activin pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.490276
RefSeq NM_031380 XM_006514340
OMIM
CCDS CCDS23990
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca