Version 5.4
Homo sapiens Gene: FSTL3
Summary
InnateDB Gene IDBG-12738.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FSTL3
Gene Name follistatin-like 3 (secreted glycoprotein)
Synonyms FLRG; FSRP
Species Homo sapiens
Ensembl Gene ENSG00000070404
Encoded Proteins
IDBP-12740
follistatin-like 3 (secreted glycoprotein)
IDBP-762159
IDBP-763216
IDBP-809524
follistatin-like 3 (secreted glycoprotein)
IDBP-809522
follistatin-like 3 (secreted glycoprotein)
IDBP-809526
follistatin-like 3 (secreted glycoprotein)
IDBP-809527
follistatin-like 3 (secreted glycoprotein)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:676365-683390
Strand Forward strand
Band p13.3
Transcripts
ENST00000166139 ENSP00000166139
ENST00000592058
ENST00000588773 ENSP00000466383
ENST00000591552 ENSP00000468558
ENST00000592947 ENSP00000483064
ENST00000589185 ENSP00000484376
ENST00000591573 ENSP00000477770
ENST00000605925 ENSP00000484412
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001968 fibronectin binding
GO:0005515 protein binding
GO:0048185 activin binding
Biological Process
GO:0001503 ossification
GO:0001822 kidney development
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007283 spermatogenesis
GO:0008584 male gonad development
GO:0022409 positive regulation of cell-cell adhesion
GO:0030324 lung development
GO:0030325 adrenal gland development
GO:0030514 negative regulation of BMP signaling pathway
GO:0032926 negative regulation of activin receptor signaling pathway
GO:0045671 negative regulation of osteoclast differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0071248 cellular response to metal ion
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0030141 secretory granule
GO:0044306 neuron projection terminus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020325
View Gene Order
ENSBTAG00000003018
Not yet available
Pathways
NETPATH
REACTOME
REACT_150276
Antagonism of Activin by Follistatin pathway
REACT_150238
Signaling by Activin pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O95633
TrEMBL A0A024R1Y8
UniProt Splice Variant
Entrez Gene 10272
UniGene Hs.529038 Hs.707253
RefSeq NM_005860
HUGO HGNC:3973
OMIM 605343
CCDS CCDS12040
HPRD
IMGT
EMBL AK291958 AY358917 BC005839 CH471242 U76702
GenPept AAC64321 AAH05839 AAQ89276 BAF84647 EAW61165 EAW61166
RNA Seq Atlas 10272

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca