Mus musculus Gene: Dlk1
Summary
InnateDB Gene IDBG-171234.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dlk1
Gene Name delta-like 1 homolog (Drosophila)
Synonyms AW742678; DLK-1; DlkI; FA1; Ly107; Peg9; pG2; pref-1; SCP1; ZOG;
Species Mus musculus
Ensembl Gene ENSMUSG00000040856
Encoded Proteins
delta-like 1 homolog (Drosophila)
delta-like 1 homolog (Drosophila)
delta-like 1 homolog (Drosophila)
delta-like 1 homolog (Drosophila)
delta-like 1 homolog (Drosophila)
delta-like 1 homolog (Drosophila)
delta-like 1 homolog (Drosophila)
delta-like 1 homolog (Drosophila)
delta-like 1 homolog (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Dlk1 is a Notch ligand that plays a critical role in the development of anti-viral immunity. Dlk1 expression in macrophages specifically regulates IFN-gamma levels from CD4(+) and CD8(+)T cells in response to influenza A H1N1 virus infection.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] DLK1 is a Notch ligand that plays a critical role in the development of anti-viral immunity. DLK1 expression in macrophages specifically regulates IFN-gamma levels from CD4(+) and CD8(+)T cells in response to influenza A H1N1 virus infection. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185559:
This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:109452823-109463336
Strand Forward strand
Band F1
Transcripts
ENSMUST00000056110 ENSMUSP00000063104
ENSMUST00000109846 ENSMUSP00000105472
ENSMUST00000109844 ENSMUSP00000105470
ENSMUST00000109843 ENSMUSP00000105469
ENSMUST00000109842 ENSMUSP00000105468
ENSMUST00000109841 ENSMUSP00000105467
ENSMUST00000124293 ENSMUSP00000133530
ENSMUST00000174539
ENSMUST00000173539 ENSMUSP00000133430
ENSMUST00000173812 ENSMUSP00000134308
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 1 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0009791 post-embryonic development
GO:0010468 regulation of gene expression
GO:0030154 cell differentiation
GO:0045087 innate immune response (InnateDB)
GO:0045746 negative regulation of Notch signaling pathway
GO:0048706 embryonic skeletal system development
Cellular Component
GO:0009897 external side of plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
Signaling by NOTCH1 in Cancer pathway
FBXW7 Mutants and NOTCH1 in Cancer pathway
Signal Transduction pathway
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
Signaling by NOTCH pathway
Signaling by NOTCH1 pathway
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
Activated NOTCH1 Transmits Signal to the Nucleus pathway
Disease pathway
KEGG
INOH
PID BIOCARTA
PID NCI
FOXA2 and FOXA3 transcription factor networks
Notch signaling pathway
Cross-References
SwissProt
TrEMBL B0LAC1 E9PVN3
UniProt Splice Variant
Entrez Gene 13386
UniGene Mm.157069
RefSeq NM_001190703 NM_001190704 NM_001190705 NM_010052
OMIM
CCDS CCDS26168 CCDS49173 CCDS49174 CCDS56863
HPRD
IMGT
MGI ID MGI:94900
MGI Symbol Dlk1
EMBL AC165954 EF437346
GenPept ABS83515
RNA Seq Atlas 13386