InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dlk1

Summary

InnateDB Gene

IDBG-171234.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dlk1

Gene Name

delta-like 1 homolog (Drosophila)

Synonyms

AW742678; DLK-1; DlkI; FA1; Ly107; Peg9; pG2; pref-1; SCP1; ZOG

Species

Mus musculus

Ensembl Gene

ENSMUSG00000040856

Encoded Proteins

IDBP-171236

delta-like 1 homolog (Drosophila)

IDBP-261522

delta-like 1 homolog (Drosophila)

IDBP-261524

delta-like 1 homolog (Drosophila)

IDBP-261526

delta-like 1 homolog (Drosophila)

IDBP-261528

delta-like 1 homolog (Drosophila)

IDBP-261530

delta-like 1 homolog (Drosophila)

IDBP-623010

delta-like 1 homolog (Drosophila)

IDBP-623009

delta-like 1 homolog (Drosophila)

IDBP-623014

delta-like 1 homolog (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22072963

Dlk1 is a Notch ligand that plays a critical role in the development of anti-viral immunity. Dlk1 expression in macrophages specifically regulates IFN-gamma levels from CD4(+) and CD8(+)T cells in response to influenza A H1N1 virus infection.

InnateDB Annotation from Orthologs

Summary

PMID 22072963

[Homo sapiens] DLK1 is a Notch ligand that plays a critical role in the development of anti-viral immunity. DLK1 expression in macrophages specifically regulates IFN-gamma levels from CD4(+) and CD8(+)T cells in response to influenza A H1N1 virus infection. (Demonstrated in mice)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000185559:
This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:109452823-109463336

Strand

Forward strand

Band

Transcripts

ENSMUST00000056110	ENSMUSP00000063104
ENSMUST00000109846	ENSMUSP00000105472
ENSMUST00000109844	ENSMUSP00000105470
ENSMUST00000109843	ENSMUSP00000105469
ENSMUST00000109842	ENSMUSP00000105468
ENSMUST00000109841	ENSMUSP00000105467
ENSMUST00000124293	ENSMUSP00000133530
ENSMUST00000174539
ENSMUST00000173539	ENSMUSP00000133430
ENSMUST00000173812	ENSMUSP00000134308

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	1 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0009791	post-embryonic development
GO:0010468	regulation of gene expression
GO:0030154	cell differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045746	negative regulation of Notch signaling pathway
GO:0048706	embryonic skeletal system development