Version 5.4
Mus musculus Gene: Kpna3
Summary
InnateDB Gene IDBG-171319.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kpna3
Gene Name karyopherin (importin) alpha 3
Synonyms IPOA4
Species Mus musculus
Ensembl Gene ENSMUSG00000021929
Encoded Proteins
IDBP-171321
karyopherin (importin) alpha 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102753:
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:61365186-61439947
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000022496 ENSMUSP00000022496
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 29 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008565 protein transporter activity
Biological Process
GO:0006606 protein import into nucleus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102753
View Gene Order
ENSBTAG00000004850
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
REACT_115831
ISG15 antiviral mechanism pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O35344
TrEMBL Q543M7
UniProt Splice Variant
Entrez Gene 16648
UniGene Mm.25548 Mm.474026
RefSeq NM_008466
OMIM
CCDS CCDS36942
HPRD
IMGT
MGI ID MGI:1100863
MGI Symbol Kpna3
EMBL AF020772 AK049373 BC026885
GenPept AAC53372 AAH26885 BAC33718
RNA Seq Atlas 16648

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca